Journal
ACS OMEGA
Volume 7, Issue 11, Pages 9909-9916Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.2c00402
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Funding
- National Natural Science Foundation of China [42176101, 41706167, 42006104]
- Zhejiang Basic Public Welfare Research Project [LGF22B020002]
- Ningbo Key Science and Technology Development Program [2021Z046]
- Public Welfare Foundation of Ningbo City [2021S059]
- National 111 Project of China [D16013]
- Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund
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In this study, two rare tetracyclic skeleton alkaloids named perinadines B and C were isolated from the marine-derived Aspergillus sp. LS116 using molecular networking. The compounds showed moderate antibacterial activity against Bacillus subtilis and were evaluated for anti-inflammatory activities in an in vivo zebra fish model.
Two rare tetracyclic skeleton alkaloids named perinadines B and C (1 and 2) were isolated as mixtures of epimers from the marine-derived Aspergillus sp. LS116 driven by molecular networking. The planar structures of 1 and 2 were characterized by comprehensive spectroscopic data. Additionally, compounds 1 and 2 showed moderate in vitro antibacterial activity against Bacillus subtilis with minimum inhibitory concentration values of 32 and 64 mu g/mL, respectively. Besides, both of the compounds were evaluated for anti-inflammatory activities in an in vivo zebra fish model.
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