Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K

Article Thermodynamics

Solubility and thermodynamic properties of nimodipine in pure and binary solvents at a series of temperatures

Shuai Yu et al.

Summary: The solubilities of nimodipine in various solvents and solvent mixtures were studied using different models, with the results providing valuable guidance for the optimization of the crystallization process in industry.

JOURNAL OF CHEMICAL THERMODYNAMICS (2021)

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Article Thermodynamics

Solubility measurement, model evaluation and Hansen solubility parameter of ipriflavone in three binary solvents

Zibo Huang et al.

Summary: The study investigated the solubility and thermodynamic properties of Ipriflavone in three binary solvents, revealing that solubility increases with solvent mass fraction and temperature, and the dissolution process is endothermic and entropy driven. Various models were used to correlate the solubility data, showing good agreement with experimental results.

JOURNAL OF CHEMICAL THERMODYNAMICS (2021)

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Article Thermodynamics

The solubility profile and dissolution thermodynamic properties of minocycline hydrochloride in some pure and mixed solvents at several temperatures

Rongrong Li et al.

Summary: The solubility of alpha-minocycline hydrochloride was higher in alcohols compared with ethyl acetate and acetonitrile, possibly due to their ability to form hydrogen bonds with the solute molecule. In mixtures of ethyl acetate + methanol, the solubility values initially increased and then decreased with the mass fraction of methanol, reaching a maximum of 6.07 x 10(-3) at w = 0.60. The dissolution process was found to be endothermic and entropy driven, with solute-solvent interactions playing a significant role in the solubility behavior.

JOURNAL OF CHEMICAL THERMODYNAMICS (2021)

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Article Chemistry, Physical

Solid-liquid phase equilibrium of clozapine in aqueous binary solvent mixtures

Shuai Yu et al.

Summary: The study determined the solid-liquid phase equilibrium solubility of clozapine in six aqueous binary solvent mixtures and found that solubility increases with temperature and the composition of good-solvent. Polarity plays a crucial role in affecting the solubility of clozapine in mixed solvents. The NRTL model was found to fit the experimental data best.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Nanoscience & Nanotechnology

Metformin Liposome-Mediated PD-L1 Downregulation for Amplifying the Photodynamic Immunotherapy Efficacy

Wei Xiong et al.

Summary: By loading metformin and IR775 into a liposome to form a composite, it can effectively inhibit the immune killing effects of T cells. This method not only reduces the expression of PD-L1 and alleviates T cell exhaustion, but also successfully suppresses tumor growth in bladder and colon cancers.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Thermodynamics

Thermodynamic analysis and molecular simulation of solid-liquid phase equilibrium of isoprenaline hydrochloride in eleven pure solvents at saturation

Renren Sun et al.

Summary: The solubility of isoprenaline hydrochloride (IPN) in various neat solvents was found to be temperature-sensitive, with an entropy-driven dissolution process that increases with temperature. Experimental data was well correlated with different models, and molecular dynamics simulation results confirmed the experimental observations.

JOURNAL OF CHEMICAL THERMODYNAMICS (2021)

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Article Thermodynamics

Solubility of 2-Amino-5-chloro-3-methylbenzoic Acid in Ten Pure Solvents and Three Groups of Binary Mixed Solvents at T=278.15-323.15 K

Jingling Ye et al.

Summary: The solubility of 2-amino-5-chloro-3-methylbenzoic acid was determined under different solvents, with temperature showing a positive correlation with solubility, and acetone being the most suitable solvent. Various models were used to fit the data, with the modified Apelblat model showing good correlation in pure solvents and the Redlich-Kister model being more suitable for binary mixed solvents. Overall, the experimental values were in good agreement with the calculated values.

JOURNAL OF CHEMICAL AND ENGINEERING DATA (2021)

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Article Thermodynamics

Densities and Apparent Molar Volumes of Aqueous Solutions of Sodium and Potassium Triflates up to High Concentrations at Temperatures 293.15-343.15 K

Lubomir Hnedkovsky et al.

Summary: The densities of aqueous solutions of sodium triflate and potassium triflate were measured and apparent molar volumes were calculated, leading to the validation of three semi-empirical fitting models.

JOURNAL OF CHEMICAL AND ENGINEERING DATA (2021)

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Article Thermodynamics

Solubility, Three-Dimensional Hansen Solubility Parameters, and Solution Thermodynamics of 3,3′-Diaminodiphenyl Sulfone in 14 Neat Solvents from 283.15 to 328.15 K

Jiahong Chen et al.

Summary: The saturation solubility data of 3,3'-diaminodiphenyl sulfone in 14 monosolvents was obtained using the saturation shake-flask technique. There were no crystalline form transformation or solvation phenomena observed after dissolution of 3,3'-diaminodiphenyl sulfone in different solvents.

JOURNAL OF CHEMICAL AND ENGINEERING DATA (2021)

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Article Thermodynamics

Hydrogen Sulfide Solubility in Aqueous N-Methylpyrrolidone Solution

Mohammad Shokouhi et al.

Summary: The experimental results show that the solubility of hydrogen sulfide in aqueous N-methylpyrrolidone solution depends on pressure, temperature, and the mole fraction of NMP, following a certain pattern.

JOURNAL OF CHEMICAL AND ENGINEERING DATA (2021)

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Article Pharmacology & Pharmacy

Enabling the direct compression of metformin hydrochloride through QESD crystallization

Jerome Hansen et al.

Summary: The study showed that the QESD crystallization technique can significantly improve the flowability and reduce storage agglomeration of metformin hydrochloride, allowing for direct compression into tablets. However, the tabletability of the material needs to be evaluated under actual production speeds, with potential solutions including reducing punch speed or using a precompression step to avoid deaeration issues caused by the porous structure of metformin agglomerates. Additionally, the influence of surfactants used in QESD crystallization on the strength of tablets produced was also analyzed due to limited literature on this topic.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Thermodynamics

Solubility Measurement and Model Correlating of 6-Propyl-2-Thiouracil in Four Binary Solvents at 278.15-323.15 K

Wenju Liu et al.

Summary: The solubility of 6-propyl-2-thiouracil was determined in various binary solvents, showing an increase with higher mass fraction of DMF. Four models were considered reliable for predicting the solubility of 6-propyl-2-thiouracil in different solvent mixtures.

JOURNAL OF CHEMICAL AND ENGINEERING DATA (2021)

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Article Thermodynamics

Solubility Measurement and Data Correlation of Metformin Hydrochloride in Four Aqueous Binary Solvents and Three Pure Solvents from 283.15 to 323.15 K

Xinyuan Sun et al.

Summary: The solubility of form A metformin hydrochloride in different solvents increases with temperature and initial water content of the binary solvents. The order of solubility in the four aqueous solvent mixtures is mainly influenced by hydrogen bond interactions. The Apelblat model can best correlate the solubility data with average relative deviations less than 6%.

JOURNAL OF CHEMICAL AND ENGINEERING DATA (2021)

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Article Chemistry, Physical

Solution thermodynamics of ceftiofur hydrochloride in pure and binary solvents

Yuan Gao et al.

Summary: The solubility of ceftiofur hydrochloride in various pure solvents and binary solvent mixtures was determined at different temperatures, showing an increase in solubility with temperature. Different models were successfully used to correlate the experimental solubility data in both pure solvents and mixed solvent systems.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Thermodynamics