Journal
PLANTS-BASEL
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/plants11060745
Keywords
RNA sequencing; metabolomics; data visualization; overrepresentation analysis; correlation; cluster analysis; principal component analysis; scientific plotting; Mapman; Mercator
Categories
Funding
- German Ministry of Education and Research BMBF [BreedPath 031B0890B]
- European Commission [731013, 824087, 739514]
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Next-generation sequencing and metabolomics data need to be visualized and further analyzed, but existing tools often require installation or manual programming. Therefore, we developed GXP, a web-based RNAseq and metabolomics data visualization and analysis tool that does not require any custom installation, manual programming, or uploading of confidential data. GXP enables users to interact with the data, perform knowledge-driven analyses, and identify candidates through visualization and data exploration. It can support and accelerate complex interdisciplinary omics projects and downstream analyses, and offers an easy way to publish data and analysis results.
Next-generation sequencing and metabolomics have become very cost and work efficient and are integrated into an ever-growing number of life science research projects. Typically, established software pipelines analyze raw data and produce quantitative data informing about gene expression or concentrations of metabolites. These results need to be visualized and further analyzed in order to support scientific hypothesis building and identification of underlying biological patterns. Some of these tools already exist, but require installation or manual programming. We developed Gene Expression Plotter (GXP), an RNAseq and Metabolomics data visualization and analysis tool entirely running in the user's web browser, thus not needing any custom installation, manual programming or uploading of confidential data to third party servers. Consequently, upon receiving the bioinformatic raw data analysis of RNAseq or other omics results, GXP immediately enables the user to interact with the data according to biological questions by performing knowledge-driven, in-depth data analyses and candidate identification via visualization and data exploration. Thereby, GXP can support and accelerate complex interdisciplinary omics projects and downstream analyses. GXP offers an easy way to publish data, plots, and analysis results either as a simple exported file or as a custom website. GXP is freely available on GitHub (see introduction)
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