4.7 Article

Cytotoxic Effects of Some Nepeta Species against Breast Cancer Cell Lines and Their Associated Phytochemical Properties

Journal

PLANTS-BASEL
Volume 11, Issue 11, Pages -

Publisher

MDPI
DOI: 10.3390/plants11111427

Keywords

Nepeta; antiproliferative effect; ursolic acid; triterpenoid

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Funding

  1. Erciyes University Scientific Research Projects Coordination Unit [TDK2020-10077]

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This study investigated the phytochemical content and cytotoxic effects of 14 Nepeta taxa collected from Turkey on breast cancer cells. Certain species of Nepeta were found to suppress the growth of breast cancer cells, and this effect was correlated with the triterpene content.
Nepeta is one of the largest genera of the Lamiaceae family. Nepeta species are commonly employed in traditional medicine for a variety of ailments, as well as food additives. In addition, they also come to the fore with their rich phytochemical content. In the present study, the quantitative phytochemical content of methanolic extracts and infusions prepared from the aerial parts of 14 Nepeta taxa collected from Turkey and their cytotoxic effects on two breast cancer cell lines, MCF-7 and MDA-MB-231, were investigated by using the MTT (3-(4,5-dimethylthiazol-2-yl))-2,5-diphenyltetrazolium-bromide) test. According to HPLC-PDA analysis, N. racemosa methanolic extract had the highest ursolic acid content with 165.9 mg/g extract. Total sterol, total iridoid, and total triterpenoid content were determined to be greatest in the methanolic extracts of N. meyeri, N. trichocalyx and N. phyllochlamys. The MTT experiment demonstrated that certain Nepeta species suppressed the growth of MCF-7 and MDA-MB-231 cells in a dose-dependent manner. Statistical analysis revealed a strong correlation between the cytotoxic effects of the extracts and their triterpene content. In conclusion, the data obtained from this study are important in terms of forming a basis for advanced anticancer activity studies on breast cancer with Nepeta sp.

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