Does the Heart Fall Asleep?-Diurnal Variations in Heart Rate Variability in Patients with Disorders of Consciousness

The current study investigated heart rate (HR) and heart rate variability (HRV) across day and night in patients with disorders of consciousness (DOC). We recorded 24-h electrocardiography in 26 patients with DOC (i.e., unresponsive wakefulness syndrome (UWS; n = 16) and (exit) minimally conscious state ((E)MCS; n = 10)). To examine diurnal variations, HR and HRV indices in the time, frequency, and entropy domains were computed for periods of clear day- (forenoon: 8 a.m.-2 p.m.; afternoon: 2 p.m.-8 p.m.) and nighttime (11 p.m.-5 a.m.). The results indicate that patients' interbeat intervals (IBIs) were larger during the night than during the day, indicating HR slowing. The patients in UWS showed larger IBIs compared to the patients in (E)MCS, and the patients with non-traumatic brain injury showed lower HRV entropy than the patients with traumatic brain injury. Additionally, higher HRV entropy was associated with higher EEG entropy during the night. Thus, cardiac activity varies with a diurnal pattern in patients with DOC and can differentiate between patients' diagnoses and etiologies. Moreover, the interaction of heart and brain appears to follow a diurnal rhythm. Thus, HR and HRV seem to mirror the integrity of brain functioning and, consequently, might serve as supplementary measures for improving the validity of assessments in patients with DOC.

Automated summary

This study investigated the changes in heart rate and heart rate variability in patients with disorders of consciousness (DOC) during the day and night. The results showed that heart rate slowed down during the night, patients in unresponsive wakefulness syndrome (UWS) had longer interbeat intervals compared to patients in (exit) minimally conscious state ((E)MCS), and patients with non-traumatic brain injury had lower heart rate variability entropy than patients with traumatic brain injury. Additionally, higher heart rate variability entropy was associated with higher EEG entropy during the night. These findings suggest that cardiac activity varies with a diurnal pattern in patients with DOC and can differentiate between patients' diagnoses and etiologies.