Journal
FOODS
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/foods11050694
Keywords
SARS-CoV-2; humic acid; fulvic acid; Zn-Se-ascorbic acid complex; antiviral activity; RT-PCR
Categories
Funding
- Higher Education Institutional Excellence Program of the Ministry of Innovation and Technology [TKP2021-EGA]
- European Union [739593: HCEMM, 712821]
- Higher Education Institutional Excellence Programme of the Ministry for Innovation and Technology in Hungary within University of Pecs
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The study demonstrates that a combination of humic substances with ascorbic acid, Se, and Zn2+ ions has significant antiviral activity against the SARS-CoV-2 virus at very low concentrations.
(1) Background: Humic substances are well-known human nutritional supplement materials and they play an important performance-enhancing role as animal feed additives. For decades, ingredients of humic substances have been proven to carry potent antiviral effects against different viruses. (2) Methods: Here, the antiviral activity of a humic substance containing ascorbic acid, Se- and Zn2+ ions intended as a nutritional supplement material was investigated against SARS-CoV-2 virus B1.1.7 Variant of Concern (Alpha Variant) in a VeroE6 cell line. (3) Results: This combination has a significant in vitro antiviral effect at a very low concentration range of its intended active ingredients. (4) Conclusions: Even picomolar concentration ranges of humic substances, Vitamin C and Zn/Se ions in the given composition, were enough to achieve 50% viral replication inhibition in the applied SARS-CoV-2 virus inhibition test.
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