Journal
FRONTIERS IN MEDICINE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2022.809292
Keywords
sepsis; chronic kidney disease; AKI (acute kidney injury); renal function decline; end-stage renal disease
Categories
Funding
- Ministry of Science and Technology, Taiwan [MOST 106-2314-B-010-039-MY3, MOST 107-2314-B-075-052, MOST 108-2314-B-075-008, MOST 109-2314-B-075-067-MY3, MOST 109-2320-B-075-006, MOST 109-2314-B-075-097-MY3, MOST 110-2312-B-075-002, MOST 110-2634-F-A49-005, MOST 110-2320-B-075-004-MY3]
- Taipei Veterans General Hospital [V107B-027, V108B-023, V108C-103, V108D42-004-MY3-2, V109B-022, V109C-114, V109D50-001-MY3-1, V109D50-001-MY3-2, V109D50-001-MY3-3, V109D50-002-MY3-3, V109E-008-5, V110C-152, V110E-003-2, V111E-002-3, V111C-171, V111C-151, V111D60-004-MY3-1]
- Taipei Veterans General Hospital, National Yang-Ming University Excellent Physician Scientists Cultivation Program [104-V-B-044]
- Taipei, Taichung, Kaohsiung Veterans General Hospital
- Academia Sinica Joint Research Program [VTA110-V1-3-1]
- Foundation for Poison Control [FPC-109-002]
- Tri-Service General Hospital
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The study revealed that patients with chronic kidney disease discharged from hospitalization for sepsis are at higher risks of subsequent renal adverse events compared to non-sepsis group.
BackgroundSepsis is known to cause renal function fluctuations during hospitalization, but whether these patients discharged from sepsis were still at greater risks of long-term renal adverse outcomes remains unknown. MethodsFrom 2011 to 2018, we included 1,12,628 patients with chronic kidney disease (CKD) aged >= 20 years. The patients with CKD were further divided into 11,661 sepsis group and 1,00,967 non-sepsis group. The following outcome of interest was included: all-cause mortality, readmission for acute kidney injury, estimated glomerular filtration rate decline >= 50% or doubling of serum creatinine, and end-stage renal disease. ResultsAfter propensity score matching, the sepsis group was at higher risks of all-cause mortality [hazard ratio (HR) 1.39, 95% CI, 1.31-1.47], readmission for acute kidney injury (HR 1.67, 95% CI 1.58-1.76), eGFR decline >= 50% or doubling of serum creatinine (HR 3.34, 95% CI 2.78-4.01), and end-stage renal disease (HR 1.43, 95% CI 1.34-1.53) than non-sepsis group. ConclusionsOur study found that patients with CKD discharged from hospitalization for sepsis have higher risks of subsequent renal adverse events.
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