4.6 Article

Association Between Extracellular Superoxide Dismutase Activity and 1-Year All-Cause Mortality in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study

Journal

FRONTIERS IN MEDICINE
Volume 9, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2022.811975

Keywords

AECOPD; extracellular superoxide dismutase (ecSOD); SOD3; mortality; prognosis

Funding

  1. National Natural Science Foundation of China [81670042, 82000045]
  2. Natural Science Foundation of Guangdong Province [2017A030313887]
  3. Guangzhou Science and Technology Project [201707010232]
  4. Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01S155]

Ask authors/readers for more resources

The study investigated the association between serum ecSOD activity and 1-year all-cause mortality in acute exacerbations of COPD (AECOPD) patients. The findings suggest that lower ecSOD activity is a strong independent predictor of 1-year all-cause mortality in AECOPD patients.
Background and ObjectivesAccumulating evidence suggests that oxidative stress is involved in the development of chronic obstructive pulmonary disease (COPD) and its progression. Activity of extracellular superoxide dismutase (ecSOD), the only extracellular enzyme eliminating superoxide radicals, has been reported to decline in acute exacerbations of COPD (AECOPD). However, the association between serum ecSOD activity and 1-year all-cause mortality in AECOPD patients remains unclear. The objective of our study was to explore the usefulness of ecSOD activity on admission in AECOPD as an objective predictor for 1-year all-cause mortality. MethodsWe measured serum ecSOD activity in AECOPD patients on admission in a prospective cohort study. We also recorded their laboratory and clinical data. Multivariate Cox regression was used to analyze the association between ecSOD activity and the risk of 1-year all-cause mortality. Restricted cubic spline curves were used to visualize the relationship between ecSOD activity and the hazard ratio of 1-year all-cause mortality. ResultsA total of 367 patients were followed up for 1 year, and 29 patients died during a 1-year follow-up period. Compared with survivors, the non-survivors were older (79.52 +/- 8.39 vs. 74.38 +/- 9.34 years old, p = 0.004) and had increased levels of tobacco consumption (47.07 +/- 41.67 vs. 33.83 +/- 31.79 pack-years, p = 0.037). Having an ecSOD activity <= 98.8 U/ml was an independent risk factor of 1-year all-cause mortality after adjustment for baseline differences, clinical variables and comorbidities [hazard ratio = 5.51, 95% confidence interval (CI): 2.35-12.95, p < 0.001]. ConclusionLower serum ecSOD activity was a strong and independent predictor of 1-year all-cause mortality in AECOPD patients.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available