Journal
FRONTIERS IN MEDICINE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2022.846173
Keywords
segmental and focal glomerulosclerosis; nephrotic syndrome (NS); renal biopsy; podocytes; glomerulopathy
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Collapsing glomerulopathy (CG) is a clinicopathologic entity characterized by glomerular collapse, podocyte hypertrophy and hyperplasia. It is more prevalent among populations with African descent. Risk factors include APOL1 gene mutations, HIV infection, and SARS-CoV-2 infection. CG presents with severe symptoms and worse prognosis compared to other FSGS subtypes.
Collapsing glomerulopathy (CG) is a clinicopathologic entity characterized by segmentar or global collapse of the glomerulus and hypertrophy and hyperplasia of podocytes. The Columbia classification of 2004 classified CG as a histological subtype of focal segmental glomerulosclerosis (FSGS). A growing number of studies have demonstrated a high prevalence of CG in many countries, especially among populations with a higher proportion of people with African descent. The present study is a narrative review of articles extracted from PubMed, Medline, and Scielo databases from September 1, 2020 to December 31, 2021. We have focused on populational studies (specially cross-sectional and cohort articles). CG is defined as a podocytopathy with a distinct pathogenesis characterized by strong podocyte proliferative activity. The most significant risk factors for CG include APOL1 gene mutations and infections with human immunodeficiency virus and severe acute respiratory syndrome coronavirus 2. CG typically presents with more severe symptoms and greater renal damage. The prognosis is notably worse than that of other FSGS subtypes.
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