☆ 4.6 Review

The Integration of Metabolomics with Other Omics: Insights into Understanding Prostate Cancer

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The implications of IDH mutations for cancer development and therapy

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Summary: The article discusses the impact of IDH mutations in various cancers, highlighting the production of oncometabolite and the importance of targeting mutant IDH for therapeutic purposes. It reviews the current understanding and available data on therapeutic strategies for IDH-mutant cancers and speculates on whether treatment approaches will converge or be context dependent based on the underlying pathogenesis.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Statins reduce castration-induced bone marrow adiposity and prostate cancer progression in bone

Tianhong Pan et al.

Summary: The study demonstrates that statins can reduce bone marrow adiposity and slow down the progression of prostate cancer in bones. By affecting the transition of BMSC to adipocytes, the progression of PCa may be delayed.

ONCOGENE (2021)

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Article Environmental Sciences

Perfluorinated iodine alkanes induce tissue-specific expression of estrogen receptor and its phosphorylation

Zhihua Ren et al.

Summary: This study investigated the effects of perfluorinated iodine alkanes (PFIs) on the expression and phosphorylation of estrogen receptors (ERs) in human-derived cell lines. The findings revealed a regulatory profile of PFIs on ER isoforms expressions and ER alpha phosphorylation, shedding light on the potential endocrine-disrupting effects of these emerging chemicals. The differential responses in breast cancer and liver cancer cells suggest tissue-specific regulation of ERs by PFIs.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Multidisciplinary Sciences

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

S. Taavitsainen et al.

Summary: The authors identified chromatin and gene expression patterns in response to enzalutamide treatment in prostate cancer using single cell-ATAC and RNAseq techniques. They found distinct chromatin landscapes associated with treatment and resistance, which could predict treatment response. Ultimately, these findings may inform clinical decision-making by revealing molecular predictors of treatment response in pre-clinical models.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

C. Kalogirou et al.

Summary: The downregulation of miR-205 promotes cholesterol synthesis and androgen receptor signaling in aggressive prostate cancer by enhancing the expression of the rate-limiting enzyme squalene epoxidase. Overexpression of squalene epoxidase in advanced prostate cancer correlates with poor survival, indicating its potential as a therapeutic target. Inhibition of squalene epoxidase with terbinafine effectively blocked tumor growth in mice and reduced levels of prostate specific antigen in late-stage prostate cancer patients.

NATURE COMMUNICATIONS (2021)

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Review Nutrition & Dietetics

Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management

Chandra K. Singh et al.

Summary: Studies have shown the importance of zinc in prostate biology and functions, with high concentrations in healthy prostates and decreased levels in prostate cancer. Zinc supplementation may not effectively increase zinc concentrations in PCa, possibly due to dysregulation of zinc transporters. Natural dietary phytochemicals may modulate zinc levels and combined with zinc, could potentially inhibit prostate cancer.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

High-resolution metabolomic biomarkers for lung cancer diagnosis and prognosis

Shi-Ang Qi et al.

Summary: This study identified key metabolites for early lung cancer screening through plasma metabolomic analysis, which could potentially be transferred onto point-of-care devices for lung cancer diagnosis and prognosis.

SCIENTIFIC REPORTS (2021)

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Article Biology

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

Joanna L. Gillis et al.

Summary: The study reveals a novel link between AR and the pentose phosphate pathway in prostate cancer, with AR indirectly increasing 6PGD expression through SREBP1. Targeting 6PGD with specific inhibitors demonstrated anti-cancer activity by inhibiting PPP, increasing AMPK activity, and reducing AR levels and activity. Co-targeting AR and 6PGD showed greater efficacy in inhibiting prostate cancer cell growth compared to single-agent therapies, suggesting a potential therapeutic strategy.

ELIFE (2021)

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Article Oncology

Plasma Metabolomics for Discovery of Early Metabolic Markers of Prostate Cancer Based on Ultra-High-Performance Liquid Chromatography-High Resolution Mass Spectrometry

Xiangping Lin et al.

Summary: Correct identification of subjects at high risk is crucial for preventing and screening prostate cancer. Metabolite analysis in biofluids has shown potential in identifying novel biomarkers for PCa. The study found dysregulation of amino acids and sphingolipid metabolism to be associated with future risk of PCa, highlighting 10 specific metabolites.

CANCERS (2021)

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Review Oncology

Metabolic Rewiring and the Characterization of Oncometabolites

Diren Beyoglu et al.

Summary: Oncometabolites are produced by cancer cells, facilitating cancer proliferation and progression. Metabolomics, utilizing mass spectrometry platforms, has defined the metabolic changes in cancer cells and uncovered potential oncometabolites.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

HO-1 Modulates Aerobic Glycolysis through LDH in Prostate Cancer Cells

Florencia Cascardo et al.

Summary: Prostate cancer is the second most diagnosed malignancy and the fifth leading cause of cancer associated death in men globally. HO-1 induction in PCa cells leads to decreased cellular metabolic rate and changes in clinical outcomes based on LDHA, LDHB, and HMOX1 expression levels.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases

Adewale Victor Aderemi et al.

Summary: Metabolomics is a branch of omics sciences that aims to identify and assess small molecules in samples for their diagnostic and therapeutic potentials. It has been utilized in various aspects of life and has shown potential in biomarker discovery for disease diagnosis and management. However, challenges remain in translating laboratory discoveries to clinical applications.

METABOLITES (2021)

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Article Medicine, Research & Experimental

Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes

Sheng-Chieh Hsu et al.

Summary: The study revealed the mechanisms of tumor cell death induced by arginine starvation, including suppression of gene expression, changes in metabolic profiles, and activation of immune responses. The dietary arginine-restriction model demonstrated that arginine starvation can suppress prostate cancer growth and enhance immune cell recruitment.

THERANOSTICS (2021)

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Article Oncology

Changes in phospholipid metabolism in exosomes of hormone-sensitive and hormone-resistant prostate cancer cells

Xianlin Yi et al.

Summary: The study reveals differences in lipid metabolism in exosomes of hormone-sensitive and hormone-resistant prostate cancer cells, indicating potential for lipid-based biomarker screening. Phospholipids show varying compositions in exosomes from different cells, highlighting the importance of phosphatidylcholine and lysophosphatidylcholine in hormone-sensitive prostate cancer. Targeting lysophosphatidylcholine, autophagy, and ferroptosis pathways may offer new therapeutic strategies. The modified PEG precipitation technique shows promise for isolating prostate cancer cell exosomes for cancer screening.

JOURNAL OF CANCER (2021)

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Article Medical Laboratory Technology

Predictive diagnosis of chronic obstructive pulmonary disease using serum metabolic biomarkers and least-squares support vector machine

Hong Zheng et al.

Summary: This study identified serum metabolic biomarkers that could be used for the diagnosis of COPD. By utilizing LS-SVM and serum metabolic biomarkers, a classifier with linear and polynomial kernels was found to have better accuracy rates and AUC values for COPD diagnosis. Artificial intelligence integrated with serum metabolic biomarkers shows great potential for aiding in COPD diagnosis.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Chemistry, Analytical

Combining the advantages of multilevel and orthogonal partial least squares data analysis for longitudinal metabolomics: Application to kidney transplantation

Yoric Gagnebin et al.

ANALYTICA CHIMICA ACTA (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Extraprostatic Uptake of 18F-Fluciclovine: Differentiation of Nonprostatic Neoplasms From Metastatic Prostate Cancer

Matthew S. Robertson et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2020)

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Article Chemistry, Analytical

Unveiling the Fragmentation Mechanisms of Modified Amino Acids as the Key for Their Targeted Identification

Maricruz Mamani-Huanca et al.

ANALYTICAL CHEMISTRY (2020)

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Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Article Oncology

RNA-seq reveals novel mechanistic targets of withaferin A in prostate cancer cells

Su-Hyeong Kim et al.

CARCINOGENESIS (2020)

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Review Biochemistry & Molecular Biology

Chemoproteomic profiling of protein-metabolite interactions

Wei Qin et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Amino acids in cancer

Elizabeth L. Lieu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

Decreased glucose bioavailability and elevated aspartate metabolism in prostate cancer cells undergoing epithelial-mesenchymal transition

Yule Chen et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Medicine, Research & Experimental

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Michael A. Kiebish et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression-An in vitro study

Vijayalakshmi N. Ayyagari et al.

PLOS ONE (2020)

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Review Oncology

Fourier Transform Infrared Spectroscopy as a Cancer Screening and Diagnostic Tool: A Review and Prospects

Kar-Yan Su et al.

CANCERS (2020)

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Article Biochemistry & Molecular Biology

High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in 'Glutamine Addiction'

Thambi Dorai et al.

BIOMOLECULES (2020)

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Article Multidisciplinary Sciences

Integrated RNA and metabolite profiling of urine liquid biopsies for prostate cancer biomarker discovery

Bongyong Lee et al.

SCIENTIFIC REPORTS (2020)

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Article Multidisciplinary Sciences

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

Arnaud Blomme et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

Targeting RET Kinase in Neuroendocrine Prostate Cancer

Halena R. VanDeusen et al.

MOLECULAR CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer

Monika Oberhuber et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

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Article Cell Biology

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Xiaoguang Liu et al.

NATURE CELL BIOLOGY (2020)

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Review Oncology

Proline Metabolism in Tumor Growth and Metastatic Progression

Cristina D'Aniello et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation

Jacob E. Moskowitz et al.

BMC CANCER (2020)

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Article Oncology

Aberrant Expression of Citrate Synthase is Linked to Disease Progression and Clinical Outcome in Prostate Cancer

Zhiduan Cai et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Review Endocrinology & Metabolism

The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

Tongxin Ge et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Article Oncology

Human Prostate Cancer Is Characterized by an Increase in Urea Cycle Metabolites

Andras Franko et al.

CANCERS (2020)

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Article Biochemical Research Methods

Investigation of spectroscopic and proteomic alterations underlying prostate carcinogenesis

Juliana Felgueiras et al.

JOURNAL OF PROTEOMICS (2020)

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Review Biochemistry & Molecular Biology

Deregulated PTEN/PI3K/AKT/mTOR signaling in prostate cancer: Still a potential druggable target?

Luca Braglia et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells

Jie Li et al.

SCIENCE SIGNALING (2020)

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Article Biochemical Research Methods

Targeted Metabolomics Analyses Reveal Specific Metabolic Alterations in High-Grade Prostate Cancer Patients

Nuria Gomez-Cebrian et al.

JOURNAL OF PROTEOME RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Aberrant activation of super enhancer and choline metabolism drive antiandrogen therapy resistance in prostate cancer

Simeng Wen et al.

ONCOGENE (2020)

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Article Multidisciplinary Sciences

Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

Jody Vykoukal et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant disease

Rebecca Smith et al.

SCIENTIFIC REPORTS (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy

Gaurav Malviya et al.

EJNMMI RESEARCH (2020)

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Article Oncology

CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer

Molishree Joshi et al.

CANCERS (2020)

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Article Medicine, Research & Experimental

An overview of advances in multi-omics analysis in prostate cancer

Enchong Zhang et al.

LIFE SCIENCES (2020)

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Review Oncology

Role of de novo cholesterol synthesis enzymes in cancer

Jie Yang et al.

JOURNAL OF CANCER (2020)

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Article Medicine, Research & Experimental

The Genomics of Prostate Cancer: A Historic Perspective

Mark A. Rubin et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2019)

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Article Oncology

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/l Deficiency Promotes Neuroendocrine Prostate Cancer

Miguel Reina-Campos et al.

CANCER CELL (2019)

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Article Oncology

Functional and Mechanistic Interrogation of BET Bromodomain Degraders for the Treatment of Metastatic Castration-resistant Prostate Cancer

Steven Kregel et al.

CLINICAL CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer

Shanshan Bai et al.

ONCOGENE (2019)

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Review Oncology

Mechanisms of PTEN loss in cancer: It's all about diversity

Virginia Alvarez-Garcia et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Prostate cancer-specific hallmarks of amino acids metabolism: Towards a paradigm of precision medicine

Vladislav Strmiska et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Review Oncology

Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment

Judyta Zabielska et al.

ANTICANCER RESEARCH (2019)

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Article Pharmacology & Pharmacy

Emerging Applications of Metabolomics in Clinical Pharmacology

Huanhuan Pang et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

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Article Biochemistry & Molecular Biology

Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector against Metabolic and Oxidative Stress in Prostate Cancer

Jodi Dougan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Medicine, Research & Experimental

Exploring the MIR143-UPAR Axis for the Inhibition of Human Prostate Cancer Cells In Vitro and In Vivo

Sven Wach et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer

Irena Saarinen et al.

EJNMMI RESEARCH (2019)

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Article Oncology

CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation

Harri M. Itkonen et al.

NEOPLASIA (2019)

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Article Biochemistry & Molecular Biology

Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma

Bei Gao et al.

METABOLITES (2019)

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Review Biochemistry & Molecular Biology

Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective

Su H. Chu et al.

METABOLITES (2019)

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Article Chemistry, Analytical

Integrated Probabilistic Annotation: A Bayesian-Based Annotation Method for Metabolomic Profiles Integrating Biochemical Connections, Isotope Patterns, and Adduct Relationships

Francesco Del Carratore et al.

ANALYTICAL CHEMISTRY (2019)

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Article Biotechnology & Applied Microbiology

Stoichiometric gene-to-reaction associations enhance model-driven analysis performance: Metabolic response to chronic exposure to Aldrin in prostate cancer

Igor Marin de Mas et al.

BMC GENOMICS (2019)

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Review Pathology

The applications of metabolomics in the molecular diagnostics of cancer

Pro Kit Cheung et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2019)

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Review Cell Biology

The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer

Hung-Chi Yang et al.

CELLS (2019)

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Article Multidisciplinary Sciences

Systematic identification of metabolites controlling gene expression in E. coli

Martin Lempp et al.

NATURE COMMUNICATIONS (2019)

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Article Nutrition & Dietetics

Metabolic Trajectories Following Contrasting Prudent and Western Diets from Food Provisions: Identifying Robust Biomarkers of Short-Term Changes in Habitual Diet

Nadine Wellington et al.

NUTRIENTS (2019)

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Article Multidisciplinary Sciences

LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1

Deven Patel et al.

SCIENTIFIC REPORTS (2019)

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Article Oncology

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

Charleen D. Adams et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2019)

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Article Genetics & Heredity

Identification of key pathways and genes in PTEN mutation prostate cancer by bioinformatics analysis

Jian Sun et al.

BMC MEDICAL GENETICS (2019)

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Article Multidisciplinary Sciences

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

Giorgia Zadra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Oncology

Effect of PTEN loss on metabolic reprogramming in prostate cancer cells

Xin Zhou et al.

ONCOLOGY LETTERS (2019)

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Review Biochemistry & Molecular Biology

Metabolomics Contributions to the Discovery of Prostate Cancer Biomarkers

Nuria Gomez-Cebrian et al.

METABOLITES (2019)

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Review Medicine, General & Internal

Metabolomics Biomarkers of Prostate Cancer: A Systematic Review

Marouane Kdadra et al.

DIAGNOSTICS (2019)

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Article Endocrinology & Metabolism

Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer

David A. Bader et al.

NATURE METABOLISM (2019)

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Article Oncology

Cornin protects SH-SY5Y cells against oxygen and glucose deprivation-induced autophagy through the PI3K/Akt/mTOR pathway

Changling Ding et al.

MOLECULAR MEDICINE REPORTS (2018)

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Review Cell Biology

AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Oncology

Serum cholesterol and risk of high-grade prostate cancer: results from the REDUCE study

Juzar Jamnagerwalla et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2018)

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Article Medicine, Research & Experimental

Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic Opportunities

Giorgia Zadra et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

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Editorial Material Cell Biology

Metabolite-Induced Protein Expression Guided by Metabolomics and Systems Biology

Martin Giera et al.

CELL METABOLISM (2018)

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Review Pathology

A review of validated biomarkers obtained through metabolomics

Angeles Lopez-Lopez et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2018)

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Article Oncology

Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer

Yaping Shao et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

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Review Endocrinology & Metabolism

From correlation to causation: analysis of metabolomics data using systems biology approaches

Antonio Rosato et al.

METABOLOMICS (2018)

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Article Oncology

Integrating biomarkers across omic platforms: an approach to improve stratification of patients with indolent and aggressive prostate cancer

Keefe Murphy et al.

MOLECULAR ONCOLOGY (2018)

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Article Biotechnology & Applied Microbiology

Metabolomics activity screening for identifying metabolites that modulate phenotype

Carlos Guijas et al.

NATURE BIOTECHNOLOGY (2018)

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Article Genetics & Heredity

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

Jingjing Chen et al.

NATURE GENETICS (2018)

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Article Genetics & Heredity

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

Ming Chen et al.

NATURE GENETICS (2018)

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Review Urology & Nephrology

Clinical implications of PTEN loss in prostate cancer

Tamara Jamaspishvili et al.

NATURE REVIEWS UROLOGY (2018)

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Review Endocrinology & Metabolism

Glucose impairments and insulin resistance in prostate cancer: the role of obesity, nutrition and exercise

K. M. Di Sebastiano et al.

OBESITY REVIEWS (2018)

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Article Oncology

p53 status in the primary tumor predicts efficacy of subsequent abiraterone and enzalutamide in castration-resistant prostate cancer

Benjamin L. Maughan et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2018)

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Article Multidisciplinary Sciences

Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression

Leena Latonen et al.

NATURE COMMUNICATIONS (2018)

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Article Medicine, Research & Experimental

The Urinary Sarcosine/Creatinine Ratio is a Potential Diagnostic and Prognostic Marker in Prostate Cancer

Meng Wang et al.

MEDICAL SCIENCE MONITOR (2018)

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Review Endocrinology & Metabolism

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

Eric S. Goetzman et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Review Medicine, General & Internal

The crucial role of multiomic approach in cancer research and clinically relevant outcomes

Miaolong Lu et al.

EPMA JOURNAL (2018)

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Article Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

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News Item Multidisciplinary Sciences

Expanded human gene tally reignites debate

Cassandra Willyard

NATURE (2018)

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Review Cell Biology

Metabolites as regulators of insulin sensitivity and metabolism

Qin Yang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Multidisciplinary Sciences

Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma

Maria K. Andersen et al.

SCIENTIFIC REPORTS (2018)

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Article Biology

Association between bivariate expression of key oncogenes and metabolic phenotypes of patients with prostate cancer

Elham Khodayari Moez et al.

COMPUTERS IN BIOLOGY AND MEDICINE (2018)

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Review Endocrinology & Metabolism

Review of recent developments in GC-MS approaches to metabolomics-based research

David J. Beale et al.

METABOLOMICS (2018)

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Article Endocrinology & Metabolism

Investigation of species and environmental effects on rhubarb roots metabolome using H-1 NMR combined with high performance thin layer chromatography

Yanhui Ge et al.

METABOLOMICS (2018)

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Article Multidisciplinary Sciences

Alterations of tumor microenvironment by nitric oxide impedes castration-resistant prostate cancer growth

Himanshu Arora et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Cell Biology

Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression

Marc Clos-Garcia et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Biochemistry & Molecular Biology

Multi-omic approach decodes paradoxes of the triple-negative breast cancer: lessons for predictive, preventive and personalised medicine

Olga Golubnitschaja et al.

AMINO ACIDS (2018)

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Article Biochemistry & Molecular Biology

GC-MS-Based Endometabolome Analysis Differentiates Prostate Cancer from Normal Prostate Cells

Ana Rita Lima et al.

METABOLITES (2018)

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Article Oncology

The Glucocorticoid Receptor Is a Key Player for Prostate Cancer Cell Survival and a Target for Improved Antiandrogen Therapy

Martin Puhr et al.

CLINICAL CANCER RESEARCH (2018)

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Review Genetics & Heredity

Beyond genomics: understanding exposotypes through metabolomics

Nicholas J. W. Rattray et al.

HUMAN GENOMICS (2018)

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Review Urology & Nephrology

The role of glucocorticoid receptor in prostate cancer progression: from bench to bedside

Jieping Hu et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2017)

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Article Oncology

A novel non-canonical Wnt signature for prostate cancer aggressiveness

Elise Sandsmark et al.

ONCOTARGET (2017)

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Article Oncology

Serum metabolomics can predict the outcome of first systematic transrectal prostate biopsy in patients with PSA < 10 ng/ml

Iulia Andras et al.

FUTURE ONCOLOGY (2017)

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Article Cell Biology

Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer

Etienne Audet-Walsh et al.

GENES & DEVELOPMENT (2017)

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Article Oncology

A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer

Hui-Ming Lin et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Medicine, General & Internal

Amino Acid Profiles of Serum and Urine in Search for Prostate Cancer Biomarkers: a Pilot Study

Pawel Derezinski et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2017)

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Article Oncology

Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer

Mark A. White et al.

MOLECULAR CANCER RESEARCH (2017)

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Article Multidisciplinary Sciences

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Amaia Zabala-Letona et al.

NATURE (2017)

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Article Genetics & Heredity

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

Tao Long et al.

NATURE GENETICS (2017)

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Letter Biochemical Research Methods

Systems biology guided by XCMS Online metabolomics

Tao Huan et al.

NATURE METHODS (2017)

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Article Endocrinology & Metabolism

Amino Acid Profiling of Zinc Resistant Prostate Cancer Cell Lines: Associations With Cancer Progression

Monika Kratochvilova et al.

PROSTATE (2017)

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Review Reproductive Biology

A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies

Lin Cheng et al.

JOURNAL OF OVARIAN RESEARCH (2017)

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Review Oncology

Next-generation metabolomics in lung cancer diagnosis, treatment and precision medicine: mini review

Li Yu et al.

ONCOTARGET (2017)

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Article Oncology

Prospective serum metabolomic profile of prostate cancer by size and extent of primary tumor

Jiaqi Huang et al.

ONCOTARGET (2017)

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Article Oncology

Increased transcriptional and metabolic capacity for lipid metabolism in the peripheral zone of the prostate may underpin its increased susceptibility to cancer

Omar Al Kadhi et al.

ONCOTARGET (2017)

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Article Oncology

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

Thomas W. Flaig et al.

ONCOTARGET (2017)

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Article Medicine, Research & Experimental

Metabolomic Profiling of Extracellular Vesicles and Alternative Normalization Methods Reveal Enriched Metabolites and Strategies to Study Prostate Cancer-Related Changes

Maija Puhka et al.

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c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks

Stefan J. Barfeld et al.

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The Metabolic Phenotype of Prostate Cancer

Eric Eidelman et al.

FRONTIERS IN ONCOLOGY (2017)

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The early metabolomic response of adipose tissue during acute cold exposure in mice

Xiyuan Lu et al.

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Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer

Niki Marie i Zacharias et al.

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Lactic Acidosis in Prostate Cancer: Consider the Warburg Effect

Johannes C. van der Mijn et al.

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Seminal plasma enables selection and monitoring of active surveillance candidates using nuclear magnetic resonance-based metabolomics: A preliminary investigation

Matthew J. Roberts et al.

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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

Gina Lee et al.

CELL (2017)

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Using Accurate Mass Gas Chromatography-Mass Spectrometry with the MINE Database for Epimetabolite Annotation

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Metabolic Portraits of Breast Cancer by HR MAS MR Spectroscopy of Intact Tissue Samples

Tonje H. Haukaas et al.

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A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype

Mariana Schroeder et al.

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Epimetabolites: discovering metabolism beyond building and burning

Megan R. Showalter et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2017)

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The future of NMR-based metabolomics

John L. Markley et al.

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The role of mitochondria in metabolism and cell death

Helin Vakifahmetoglu-Norberg et al.

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INTEGRATE: gene fusion discovery using whole genome and transcriptome data

Jin Zhang et al.

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Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarker Involved in Prostate Cancer

Shancheng Ren et al.

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Protein acetylation in metabolism - metabolites and cofactors

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Integration of tissue metabolomics, transcriptomics and immunohistochemistry reveals ERG- and gleason score-specific metabolomic alterations in prostate cancer

Sebastian Meller et al.

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Pyranocoumarin Tissue Distribution, Plasma Metabolome and Prostate Transcriptome Impacts of Sub-Chronic Exposure to Korean Angelica Supplement in Mice

Jinhui Zhang et al.

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IDH mutations in cancer and progress toward development of targeted therapeutics

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Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study

Tilman Kuehn et al.

BMC MEDICINE (2016)

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Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

Rachel S. Kelly et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2016)

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Prospective serum metabolomic profiles of prostate cancer by size and extent of primary tumor

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Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth

M. Aggarwal et al.

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Metabolic targets for potential prostate cancer therapeutics

Jeffrey Twum-Ampofo et al.

CURRENT OPINION IN ONCOLOGY (2016)

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Rania Ibrahim et al.

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Undercover: gene control by metabolites and metabolic enzymes

Jan A. van der Knaap et al.

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One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling

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Untargeted Metabolomics Strategies-Challenges and Emerging Directions

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Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells

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Response of Degarelix treatment in human prostate cancer monitored by HR-MAS 1H NMR spectroscopy

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The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

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Emerging applications of metabolomics in drug discovery and precision medicine

David S. Wishart

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NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics

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Biomarker Discovery in Human Prostate Cancer: an Update in Metabolomics Studies

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Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer

Ailin Falkmo Hansen et al.

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A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments

Anthony C. Dona et al.

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Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016

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A functional variant in miR-143 promoter contributes to prostate cancer risk

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Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

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Cancer Metabolomics and the Human Metabolome Database

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Cancer metabolomics in basic science perspective

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Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach

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Targeting PI3K/Akt/mTOR signaling pathway in the treatment of prostate cancer radioresistance

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Multiplexed separations for biomarker discovery in metabolomics: Elucidating adaptive responses to exercise training

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Rewired Metabolism in Drug-resistant Leukemia Cells A METABOLIC SWITCH HALLMARKED BY REDUCED DEPENDENCE ON EXOGENOUS GLUTAMINE

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Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer

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Metabolomic profiling of hormone-dependent cancers: a bird's eye view

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Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case

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mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

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Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case-control study

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Robust Selection Algorithm (RSA) for Multi-Omic Biomarker Discovery; Integration with Functional Network Analysis to Identify miRNA Regulated Pathways in Multiple Cancers

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Targeting prostate cancer cell metabolism: impact of hexokinase and CPT-1 enzymes

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Targeting hexokinase 2 in castration-resistant prostate cancer

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PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance

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Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza

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Plk1 Inhibition Enhances the Efficacy of Androgen Signaling Blockade in Castration-Resistant Prostate Cancer

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AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer

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Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

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CURRENT PHARMACEUTICAL DESIGN (2014)

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Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer

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Sarcosine and other metabolites along the choline oxidation pathway in relation to prostate cancer-A large nested case-control study within the JANUS cohort in Norway

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Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

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MS-GF plus makes progress towards a universal database search tool for proteomics

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Potential Urinary miRNA Biomarker Candidates for the Accurate Detection of Prostate Cancer among Benign Prostatic Hyperplasia Patients

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Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth

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Clinical Use of [-2] proPSA (p2PSA) and Its Derivatives (%p2PSA and Prostate Health Index) for the Detection of Prostate Cancer: A Review of the Literature

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Cholesterol accumulation in prostate cancer: A classic observation from a modern perspective

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New Opportunities from the Cancer Metabolome

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A Genome-Wide Assessment of Variability in Human Serum Metabolism

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Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells

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Effects of leucine and its metabolite -hydroxy--methylbutyrate on human skeletal muscle protein metabolism

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MOLECULAR ASPECTS OF MEDICINE (2013)

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Androgens Promote Prostate Cancer Cell Growth through Induction of Autophagy

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Translational biomarker discovery in clinical metabolomics: an introductory tutorial

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Cell Metabolomics

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OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2013)

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Spermine and Citrate as Metabolic Biomarkers for Assessing Prostate Cancer Aggressiveness

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α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S

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Castration-induced testosterone deficiency increases fasting glucose associated with hepatic and extra-hepatic insulin resistance in adult male rats

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Functional p53 determines docetaxel sensitivity in prostate cancer cells

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Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

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Biomarker Discovery and Translation in Metabolomics

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CURRENT METABOLOMICS (2013)

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A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products

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Kidney Tumor Biomarkers Revealed by Simultaneous Multiple Matrix Metabolomics Analysis

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The role of choline in prostate cancer

Hussain Mohamad Awwad et al.

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Serum Glutamate Levels Correlate with Gleason Score and Glutamate Blockade Decreases Proliferation, Migration, and Invasion and Induces Apoptosis in Prostate Cancer Cells

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Cholesterol and prostate cancer

Kristine Pelton et al.

CURRENT OPINION IN PHARMACOLOGY (2012)

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Pathway-directed weighted testing procedures for the integrative analysis of gene expression and metabolomic data

Laila M. Poisson et al.

GENOMICS (2012)

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Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression

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Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells

Wen-Chin Huang et al.

MOLECULAR CANCER RESEARCH (2012)

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

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Metabolomics: the apogee of the omics trilogy

Gary J. Patti et al.

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Grahame Hardie et al.

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Robert H. Weiss et al.

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PROSTAGLANDINS & OTHER LIPID MEDIATORS (2012)

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The role of zinc transporter ZIP4 in prostate carcinoma

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UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2012)

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Functional Metabolic Screen Identifies 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 as an Important Regulator of Prostate Cancer Cell Survival

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Metabolomics as a hypothesis-generating functional genomics tool for the annotation of Arabidopsis thaliana genes of unknown function

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Glycogen synthesis is induced in hypoxia by the hypoxia-inducible factor and promotes cancer cell survival

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General Report & Recommendations in Predictive, Preventive and Personalised Medicine 2012: White Paper of the European Association for Predictive, Preventive and Personalised Medicine

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Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

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The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

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Zinc is decreased in prostate cancer: an established relationship of prostate cancer!

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Metabolic alterations and targeted therapies in prostate cancer

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The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer

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MODERN PATHOLOGY (2011)

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miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS

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Human metabolic individuality in biomedical and pharmaceutical research

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Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers

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MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors

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The Human Serum Metabolome

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The Role of the Transcription Factor SIM2 in Prostate Cancer

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Efforts to resolve the contradictions in early diagnosis of prostate cancer: a comparison of different algorithms of sarcosine in urine

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PROSTATE CANCER AND PROSTATIC DISEASES (2011)

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

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Otto Warburg's contributions to current concepts of cancer metabolism

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Metabolomics: A Novel Approach to Early and Noninvasive Prostate Cancer Detection

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The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway

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CELL (2010)

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The AMPK-FoxO3A axis as a target for cancer treatment

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Sarcosine in Urine after Digital Rectal Examination Fails as a Marker in Prostate Cancer Detection and Identification of Aggressive Tumours

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Vitamin Bs, One Carbon Metabolism and Prostate Cancer

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BioNumbers-the database of key numbers in molecular and cell biology

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Men with Low Serum Cholesterol Have a Lower Risk of High-Grade Prostate Cancer in the Placebo Arm of the Prostate Cancer Prevention Trial

Elizabeth A. Platz et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2009)

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Article Multidisciplinary Sciences

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Arun Sreekumar et al.

NATURE (2009)

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Article Multidisciplinary Sciences

miR-143 Interferes with ERK5 Signaling, and Abrogates Prostate Cancer Progression in Mice

Cyrielle Clape et al.

PLOS ONE (2009)

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Article Oncology

Prostatic fluid electrolyte composition for the screening of prostate cancer: a potential solution to a major problem

L. C. Costello et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2009)

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Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

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Article Oncology

Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-κB and reduces the malignant potential of prostate cancer cells in vitro and in vivo

Konstantin Golovine et al.

CLINICAL CANCER RESEARCH (2008)

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Article Microbiology

Glutamate metabolism in Bacillus subtilis:: Gene expression and enzyme activities evolved to avoid futile cycles and to allow rapid responses to perturbations of the system

Fabian M. Commichau et al.

JOURNAL OF BACTERIOLOGY (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy

Mark G. Swanson et al.

MAGNETIC RESONANCE IN MEDICINE (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using H-1 HR-MAS spectroscopy of biopsy tissues

May-Britt Tessem et al.

MAGNETIC RESONANCE IN MEDICINE (2008)

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Article Endocrinology & Metabolism

Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-κB-dependent pathway

Konstantin Golovine et al.

PROSTATE (2008)

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Article Endocrinology & Metabolism

Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues

Andrew C. Goodwin et al.

PROSTATE (2008)

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Article Genetics & Heredity

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

Christian Gieger et al.

PLOS GENETICS (2008)

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Article Biochemical Research Methods

Current Progress in computational metabolomics

David S. Wishart

BRIEFINGS IN BIOINFORMATICS (2007)

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Article Biochemistry & Molecular Biology

hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands

Mohamed M. Desouki et al.

MOLECULAR CANCER (2007)

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Review Spectroscopy

Mass spectrometry-based omics technologies in cancer diagnostics

Xuewu Zhang et al.

MASS SPECTROMETRY REVIEWS (2007)

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Article Genetics & Heredity

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models

Marc-Emmanuel Dumas et al.

NATURE GENETICS (2007)

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Article Oncology

Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer

Yu-Chuen Huang et al.

CLINICAL CANCER RESEARCH (2007)

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Article Chemistry, Analytical

Metabolomics: The greatest omics of them all?

Danielle Ryan et al.

ANALYTICAL CHEMISTRY (2006)

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Review Biochemistry & Molecular Biology

Rheostat control of gene expression by metabolites

Andreas G. Ladurner

MOLECULAR CELL (2006)

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Article Oncology

Diverse effects of zinc on NF-κB and AP-1 transcription factors:: implications for prostate cancer progression

Robert G. Uzzo et al.

CARCINOGENESIS (2006)

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Article Biochemistry & Molecular Biology

Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues

Keshav K. Singh et al.

MOLECULAR CANCER (2006)

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Article Biochemistry & Molecular Biology

Prevalent mutations in prostate cancer

JT Dong

JOURNAL OF CELLULAR BIOCHEMISTRY (2006)

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Review Oncology

Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer

Y. Liu

PROSTATE CANCER AND PROSTATIC DISEASES (2006)

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Review Pathology

Altered metabolism and mitochondrial genome in prostate cancer

GD Dakubo et al.

JOURNAL OF CLINICAL PATHOLOGY (2006)

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Article Oncology

High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB

T Van de Sande et al.

JOURNAL OF PATHOLOGY (2005)

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Article Biochemical Research Methods

High resolution Ultra performance liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies

ID Wilson et al.

JOURNAL OF PROTEOME RESEARCH (2005)

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Article Endocrinology & Metabolism

Metabolomics: building on a century of biochemistry to guide human health

J. Bruce German et al.

METABOLOMICS (2005)

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Article Urology & Nephrology

A decrease in 1H nuclear magnetic resonance spectroscopically determined citrate in human seminal fluid accompanies the development of prostate adenocarcinoma

TA Averna et al.

JOURNAL OF UROLOGY (2005)

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Article Multidisciplinary Sciences

Control of gene expression by a natural metabolite-responsive ribozyme

WC Winkler et al.

NATURE (2004)

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Article Physiology

Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers

RD Palmiter et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)

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Article Physiology

The SLC39 family of metal ion transporters

DJ Eide

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)

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Review Oncology

Metabolic profiles of cancer cells

JL Griffin et al.

NATURE REVIEWS CANCER (2004)

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Article Biochemistry & Molecular Biology

Fatty acid synthase: A metabolic oncogene in prostate cancer?

A Baron et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

Androgens, lipogenesis and prostate cancer

JV Swinnen et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2004)

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Metabolomics and systems biology: making sense of the soup

DB Kell

CURRENT OPINION IN MICROBIOLOGY (2004)

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The challenges of modeling mammalian biocomplexity

JK Nicholson et al.

NATURE BIOTECHNOLOGY (2004)

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Direct effect of zinc on mitochondrial apoptogenesis in prostate cells

P Feng et al.

PROSTATE (2002)

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In vitro estrogen receptor binding of PCBs:: Measured activity and detection of hydroxylated metabolites in a recombinant yeast assay

AC Layton et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2002)

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Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

SU Ruepp et al.

TOXICOLOGICAL SCIENCES (2002)

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Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer

JV Swinnen et al.

INTERNATIONAL JOURNAL OF CANCER (2002)

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Review Oncology

The development of androgen-independent prostate cancer

BJ Feldman et al.

NATURE REVIEWS CANCER (2001)

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Effects of pinostrobin on estrogen metabolism and estrogen receptor transactivation

JC Le Bail et al.

CANCER LETTERS (2000)

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Article Biochemistry & Molecular Biology

Functional expression of the human hZIP2 zinc transporter

LA Gaither et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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