4.3 Review

Targeted temperature management after out of hospital cardiac arrest: quo vadis?

Related references

Note: Only part of the references are listed.
Article Critical Care Medicine

Effects of targeted temperature management at 33 °C vs. 36 °C on comatose patients after cardiac arrest stratified by the severity of encephalopathy

Sjoukje Nutma et al.

Summary: By conducting a study on 479 adult comatose post-cardiac arrest patients, it was found that TTM at 33°C had better outcomes in treating patients with moderate encephalopathy, while both 33°C and 36°C had similar outcomes in treating patients with mild encephalopathy. These results support the inclusion of predefined subgroup analysis based on EEG measures of the severity of encephalopathy in future clinical trials.

RESUSCITATION (2022)

Article Critical Care Medicine

ERC-ESICM guidelines on temperature control after cardiac arrest in adults

Jerry P. Nolan et al.

Summary: These guidelines provide evidence-based recommendations for temperature control in comatose adults after resuscitation from cardiac arrest, including continuous monitoring of core temperature, prevention of fever, and recommendations against active rewarming and prehospital cooling.

RESUSCITATION (2022)

Review Multidisciplinary Sciences

The evolution of hypothermia for neuroprotection after cardiac arrest: a history in the making

Alexander Presciutti et al.

Summary: Hypothermia has been utilized as a therapeutic method in modern medicine since the early 20th century, with ongoing advancements to improve patient outcomes. While progress has been made, the ideal therapeutic approach and strategies to minimize adverse events are still being defined and further work is necessary to optimize the neuroprotective effects of hypothermia for comatose survivors of cardiac arrest.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2022)

Article Medicine, General & Internal

Clinical Outcomes with Targeted Temperature Management (TTM) in Comatose Out-of-Hospital Cardiac Arrest Patients-A Retrospective Cohort Study

Niels T. B. Scholte et al.

Summary: This study evaluated the effects of shifting targeted temperature management (TTM) strategy from 33 degrees C to 36 degrees C in comatose out-of-hospital cardiac arrest (OHCA) patients. The results showed no differences in clinical outcomes, including 90-day mortality and favorable neurological outcome at ICU discharge, between the two TTM strategies. These findings help to support previous trial results and provide guidance for the implementation of TTM.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Cardiac & Cardiovascular Systems

Haemodynamics and vasopressor support during prolonged targeted temperature management for 48 hours after out-of-hospital cardiac arrest: a post hoc substudy of a randomised clinical trial

Johannes Grand et al.

Summary: Prolonged targeted temperature management at 33 degrees C for 48 hours was associated with higher vasopressor requirement, but no detrimental effects on hemodynamics were observed.

EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE (2021)

Article Medicine, General & Internal

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest The CAPITAL CHILL Randomized Clinical Trial

Michel Le May et al.

Summary: This study compared the clinical outcomes of comatose survivors of out-of-hospital cardiac arrest with target temperatures of 31 degrees C and 34 degrees C, and found that there was no significant difference in all-cause mortality or poor neurologic outcome between the two groups.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2021 Update A Report From the American Heart Association

Salim S. Virani et al.

Summary: The American Heart Association, in partnership with the National Institutes of Health, publishes annual statistics on heart disease, stroke, and cardiovascular risk factors, including the impact of health behaviors and factors on cardiovascular health. The Statistical Update covers a range of clinical heart and circulatory conditions, providing data on quality of care, procedures, and economic costs. It serves as a critical resource for various stakeholders seeking the best available data on these factors and conditions.

CIRCULATION (2021)

Review Critical Care Medicine

Targeted temperature management in adult cardiac arrest: Systematic review and meta- analysis

Asger Granfeldt et al.

Summary: A systematic review and meta-analysis on targeted temperature management in adult cardiac arrest patients concluded that targeting 32-34 degrees Celsius did not lead to improved outcomes compared to normothermia. Initiating targeted temperature management before hospital arrival also showed no effect on survival or favorable neurologic outcomes. These findings suggest a need for updating international cardiac arrest guidelines.

RESUSCITATION (2021)

Article Critical Care Medicine

Insights from patients screened but not randomised in the HYPERION trial

J. B. Lascarrou et al.

Summary: Patients who were screened but not enrolled in the HYPERION trial showed better functional outcomes compared to those included in the trial. There was considerable variability in hypothermia treatment and functional outcomes among non-included patients across different centers. The findings suggest important considerations regarding patient selection criteria and the generalizability of trial results to clinical practice.

ANNALS OF INTENSIVE CARE (2021)

Article Critical Care Medicine

European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021 Post-resuscitation care

Jerry P. Nolan et al.

Summary: The guidelines cover various aspects of care after cardiac arrest, including diagnosis, oxygenation and ventilation control, hemodynamic monitoring, and prognostication.

RESUSCITATION (2021)

Review Critical Care Medicine

Targeted temperature management after cardiac arrest. A systematic review and meta-analysis of animal studies

Jasmin Arrich et al.

Summary: This systematic review and meta-analysis found a strong beneficial effect of targeted temperature management (TTM) compared to normothermia on neurologic outcomes in animal cardiac arrest models. Factors such as faster cooling rates, lower target temperature of TTM, and shorter duration of cooling were associated with an increasing effect size of TTM.

RESUSCITATION (2021)

Article Critical Care Medicine

Changes in temperature management and outcome after out-of-hospital cardiac arrest in United Kingdom intensive care units following publication of the targeted temperature management trial

J. P. Nolan et al.

Summary: The study investigated the impact of the publication of the TTM trial on the trends in temperature management and outcome following admission to UK ICUs for OHCA patients. Results showed higher temperature and increased fever rates in the post-TTM cohort, but no significant change in mortality after adjusting for time trend and variation between critical care units.

RESUSCITATION (2021)

Review Critical Care Medicine

Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets

Shannon M. Fernando et al.

Summary: The study suggests that mild, moderate, or deep hypothermia may not improve survival or functional outcome compared to normothermia in comatose survivors of out-of-hospital cardiac arrest. Moderate and deep hypothermia were found to be associated with a higher incidence of arrhythmia.Routine use of moderate or deep hypothermia in these patients may potentially cause more harm than benefit.

INTENSIVE CARE MEDICINE (2021)

Article Medicine, General & Internal

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest

Josef Dankiewicz et al.

Summary: A randomized trial comparing hypothermia and normothermia treatment after out-of-hospital cardiac arrest showed no significant differences in death or functional outcomes at 6 months. The hypothermia group had a higher incidence of arrhythmia resulting in hemodynamic compromise compared to the normothermia group.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Letter Medicine, General & Internal

Targeted Temperature Management after Cardiac Arrest

Giuseppe Ristagno et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Critical Care Medicine

High Quality Targeted Temperature Management (TTM) After Cardiac Arrest

Fabio Silvio Taccone et al.

CRITICAL CARE (2020)

Article Critical Care Medicine

Meta-analysis of targeted temperature management in animal models of cardiac arrest

Hilmer Olai et al.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2020)

Review Anesthesiology

Postresuscitation Care after Out-of-hospital Cardiac Arrest

Hans Kirkegaard et al.

ANESTHESIOLOGY (2019)

Article Medicine, General & Internal

Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm

J. -B. Lascarrou et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Critical Care Medicine

Arrest etiology among patients resuscitated from cardiac arrest

Niel Chen et al.

RESUSCITATION (2018)

Article Cardiac & Cardiovascular Systems

Prognostic Impact of Acute Myocardial Infarction in Patients Presenting With Ventricular Tachyarrhythmias and Aborted Cardiac Arrest

Michael Behnes et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

Article Medicine, General & Internal

Temporal Trends in the Use of Therapeutic Hypothermia for Out-of-Hospital Cardiac Arrest

Steven M. Bradley et al.

JAMA NETWORK OPEN (2018)

Article Medicine, General & Internal

Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest A Randomized Clinical Trial

Hans Kirkegaard et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

Article Cardiac & Cardiovascular Systems

Direct Transport to a Percutaneous Cardiac Intervention Center and Outcomes in Patients With Out-of-Hospital Cardiac Arrest

Kristian Kragholm et al.

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES (2017)

Review Critical Care Medicine

Pharmacokinetic and Other Considerations for Drug Therapy During Targeted Temperature Management

Katlynd M. Sunjic et al.

CRITICAL CARE MEDICINE (2015)

Article Medicine, General & Internal

Effect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac Arrest A Randomized Clinical Trial

Francis Kim et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

Article Medicine, General & Internal

Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest

Niklas Nielsen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Critical Care Medicine

Sedation Confounds Outcome Prediction in Cardiac Arrest Survivors Treated with Hypothermia

Edgar A. Samaniego et al.

NEUROCRITICAL CARE (2011)

Article Anesthesiology

Outcome, timing and adverse events in therapeutic hypothermia after out-of-hospital cardiac arrest

N. Nielsen et al.

ACTA ANAESTHESIOLOGICA SCANDINAVICA (2009)

Article Medicine, General & Internal

Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia

SA Bernard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Medicine, General & Internal

Hyperthermia after cardiac arrest is associated with an unfavorable neurologic outcome

A Zeiner et al.

ARCHIVES OF INTERNAL MEDICINE (2001)