Journal
MICROORGANISMS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms10030506
Keywords
Acinetobacter baumannii; Stenotrophomonas maltophilia; photodynamic therapy; biofilms; natural photosensitizers; riboflavin; chlorophyllin; photostability
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Funding
- European Social Fund [09.3.3-LMT-K-712]
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Antimicrobial photodynamic therapy (aPDT) based on riboflavin and chlorophyllin can effectively inactivate Acinetobacter baumannii and Stenotrophomonas maltophilia, especially for biofilm bacteria.
Acinetobacter baumannii and Stenotrophomonas maltophilia are opportunistic pathogens causing hospital infections with limited treatment options due to bacterial multidrug resistance. Here, we report that antimicrobial photodynamic therapy (aPDT) based on the natural photosensitizers riboflavin and chlorophyllin inactivates A. baumannii and S. maltophilia. The riboflavin and chlorophyllin photostability experiments assessed the photomodifications of photosensitizers under the conditions subsequently used to inactivate A. baumannii and S. maltophilia. A. baumannii planktonic cells were more sensitive to riboflavin-aPDT, while biofilm bacteria were more efficiently inactivated by chlorophyllin-aPDT. S. maltophilia planktonic and biofilm cells were more susceptible to chlorophyllin-aPDT compared to riboflavin-aPDT. The results suggest that riboflavin- and chlorophyllin-aPDT can be considered as a potential antimicrobial treatment for A. baumannii and S. maltophilia inactivation.
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