Journal
ANTIOXIDANTS
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/antiox11050892
Keywords
antitumoral; Ehrlich ascites carcinoma; flaxseed; antioxidant; anti-inflammatory
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The ethanol extract of flaxseed was found to have significant antitumor, antioxidant, and anti-inflammatory effects. It exhibited potent in vitro antioxidant activity and inhibitory effects on different cell lines. In vivo studies showed that the extract reduced tumor growth and oxidative stress in mice. The phenolic content and antioxidant and anti-inflammatory properties of the extract are believed to contribute to its antiproliferative activity.
The antitumoral, antioxidant, and anti-inflammatory effects of flaxseed ethanol extract was screened. Phytochemical analysis was performed by measuring the total phenolic content and by HPLC-DAD-ESI MS. In vitro antiproliferative activity was appreciated by MMT test of four adenocarcinomas and two normal cell lines. In vitro, antioxidant activity was evaluated by DPPH, FRAP, H2O2, and NO scavenging tests. The in vivo growth inhibitory activity against Ehrlich ascites carcinoma (EAC) in female BALB/c mice was determined using the trypan blue test. In EAC mice serum and ascites total oxidative status, total antioxidant reactivity, oxidative stress index, malondialdehyde, total thiols, total nitrites, 3-nitrotyrosine, and NFkB were measured. The phytochemical analysis found an significant content of phenols, with lignans having the highest concentration. The extract had an significant in vitro antioxidant effect and different inhibitory effects on different cell lines. After treatment of EAC mice with flaxseeds extract, body weight, ascites volume and viable tumour cell count, serum and ascites oxidative stress, and inflammatory markers decreased significantly. The ethanol flaxseeds extract has potential antiproliferative activity against some ovary and endometrial malignant cells and EAC. This effect can be attributed to the phenols content, and its antioxidant and anti-inflammatory activity.
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