Journal
ANTIOXIDANTS
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/antiox11051028
Keywords
Alzheimer's disease; amyloid-beta; exercise; metabolism; peripheral organs; free radicals
Funding
- Innovation and Technology Ministry, Hungary [126823]
- University of Physical Education [TKP2020-NKA-17, TKP2021-EGA-37]
Ask authors/readers for more resources
Alzheimer's disease is a complex disorder that affects not only the brain but also other organs in the body. Regular physical activity has been found to have a positive impact on the disease, although effective medications have not yet been discovered.
Alzheimer's disease (AD) is a progressive degenerative disorder and a leading cause of dementia in the elderly. The etiology of AD is multifactorial, including an increased oxidative state, deposition of amyloid plaques, and neurofibrillary tangles of the tau protein. The formation of amyloid plaques is considered one of the first signs of the illness, but only in the central nervous system (CNS). Interestingly, results indicate that AD is not just localized in the brain but is also found in organs distant from the brain, such as the cardiovascular system, gut microbiome, liver, testes, and kidney. These observations make AD a complex systemic disorder. Still, no effective medications have been found, but regular physical activity has been considered to have a positive impact on this challenging disease. While several articles have been published on the benefits of physical activity on AD development in the CNS, its peripheral effects have not been discussed in detail. The provocative question arising is the following: is it possible that the beneficial effects of regular exercise on AD are due to the systemic impact of training, rather than just the effects of exercise on the brain? If so, does this mean that the level of fitness of these peripheral organs can directly or indirectly influence the incidence or progress of AD? Therefore, the present paper aims to summarize the systemic effects of both regular exercise and AD and point out how common exercise-induced adaptation via peripheral organs can decrease the incidence of AD or attenuate the progress of AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available