The Relationship between Cancer and Paraoxonase 1

Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. This review focuses on the relationship between PON1 and cancer. The data suggest that PON1, oxidative stress, chronic inflammation, and cancer are closely linked. Certainly, the gene expression of PON1 will remain challenging to study. Therefore, targeting PON1, redox-sensitive pathways, and transcription factors promise prevention and therapy in the development of several diseases, including cancer.

Automated summary

Studies have shown a close relationship between PON1, oxidative stress, chronic inflammation, and cancer, while the study of PON1 gene expression remains challenging. Targeting PON1, redox-sensitive pathways, and transcription factors holds promise for the prevention and treatment of various diseases.