4.7 Article

5-Methyltetrahydrofolate Attenuates Oxidative Stress and Improves Kidney Function in Acute Kidney Injury through Activation of Nrf2 and Antioxidant Defense

Related references

Note: Only part of the references are listed.
Review Urology & Nephrology

Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection

Holger Scholz et al.

Summary: The authors discuss the specific kidney regions that are at particular risk of injury, and how this information can help in finding new ways to mitigate injury and avoid permanent damage. They suggest that the physiological heterogeneity of the kidney should be considered when exploring novel renoprotective strategies, such as improving kidney tissue oxygenation and modulating cellular energy metabolism.

NATURE REVIEWS NEPHROLOGY (2021)

Review Biochemistry & Molecular Biology

Targeting oxidative stress, a crucial challenge in renal transplantation outcome

Romain Carcy et al.

Summary: Disorders characterized by ischemia/reperfusion (I/R) are the most common causes of debilitating diseases and death in stroke, cardiovascular ischemia, acute kidney injury or organ transplantation. During transplantation, the I/R step defines both the amplitude of the damages to the graft and the functional recovery outcome. Oxidative stress plays a crucial role in cell death and tissue damage, and finding treatments to reduce or prevent oxidative stress in ischemic pathologies is a key goal for better outcomes in organ transplantation.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Low Dose of Folic Acid Can Ameliorate Hyperhomocysteinemia-Induced Cardiac Fibrosis and Diastolic Dysfunction in Spontaneously Hypertensive Rats

Ping Cao et al.

Summary: The results of the study suggest that folic acid treatment can ameliorate Hhcy-induced cardiac fibrosis and diastolic dysfunction in SHR, possibly through activation of the Nrf2/HO-1 pathway and inhibition of oxidative stress. High-dose folic acid did not show any additional benefit over low-dose folic acid in mitigating cardiac injury.

INTERNATIONAL HEART JOURNAL (2021)

Review Biotechnology & Applied Microbiology

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

Henry Jay Forman et al.

Summary: Oxidative stress plays a role in various diseases, and understanding the mechanisms behind antioxidants and how to enhance antioxidant defences may lead to greater pharmacological success.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Environmental Sciences

Oxidative Stress in Non-Dialysis-Dependent Chronic Kidney Disease Patients

Patricia Tomas-Simo et al.

Summary: The study found an active grade of oxidative stress in CKD patients from the early stages onwards, with increasing oxidative state as kidney function declined. Oxidative stress-related alterations were significantly greater in CKD patients compared to healthy controls, showing significant differences between CKD stages. Future research is warranted in this area to provide clearer results.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Immunology

Ischemia-Reperfusion Injury Reduces Kidney Folate Transporter Expression and Plasma Folate Levels

Cheng Yang et al.

Summary: Acute kidney injury downregulates renal folate transporter expression, leading to reduced folate uptake by tubular cells and contributing to low folate status in AKI patients.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Effects of Folic Acid Supplementation on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Omid Asbaghi et al.

Summary: Folic acid supplementation significantly increased serum concentrations of glutathione and total antioxidant capacity, while decreasing serum concentrations of malondialdehyde.

ANTIOXIDANTS (2021)

Review Medicine, General & Internal

A Review of Natural Products for Prevention of Acute Kidney Injury

Hyun Goo Kang et al.

Summary: This paper summarizes the results of studies on natural products related to acute kidney injury (AKI) and reviews the mechanisms by which these natural products demonstrate efficacy in preventing and treating AKI. Many natural products have shown potential in preventing and treating AKI, suggesting their potential as tools in drug development, and offering insight into additional mechanisms and meta-analysis for future research in natural products.

MEDICINA-LITHUANIA (2021)

Review Biochemistry & Molecular Biology

Folic acid-induced animal model of kidney disease

Liang-Jun Yan

Summary: The kidneys are vulnerable to both acute kidney injury (AKI) and chronic kidney disease (CKD), with animal models being crucial for studying the pathological mechanisms of kidney disease. This article reviews a widely used animal model of kidney disease induced by folic acid (FA), discussing the major mechanisms of FA-induced kidney injury and its application in testing therapeutic approaches.

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function

Xiaozhen Dai et al.

TRENDS IN MOLECULAR MEDICINE (2020)

Article Multidisciplinary Sciences

Micronutrients in critically ill patients with severe acute kidney injury - a prospective study

Marlies Ostermann et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

Kidney Ischemia-Reperfusion Decreases Hydrogen Sulfide and Increases Oxidative Stress in the Heart

Charith U. B. Wijerathne et al.

BIOMOLECULES (2020)

Article Biochemistry & Molecular Biology

Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels

Lisanne Boekhoud et al.

ANTIOXIDANTS (2020)

Article Cell Biology

The Effects of Folic Acid Administration on Cardiac Oxidative Stress and Cardiovascular Biomarkers in Diabetic Rats

Slavica Mutavdzin et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Biochemistry & Molecular Biology

Redox regulation by NRF2 in aging and disease

Cody J. Schmidlin et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Toxicology

Safety evaluation of calcium L-methylfolate

K. E. Niederberger et al.

TOXICOLOGY REPORTS (2019)

Review Cell Biology

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

Meng-yu Wu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Urology & Nephrology

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI

Diego Martin-Sanchez et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Review Nutrition & Dietetics

Protective Role for Antioxidants in Acute Kidney Disease

Joanne M. Dennis et al.

NUTRIENTS (2017)

Review Pharmacology & Pharmacy

Role of folate in nonalcoholic fatty liver disease

Victoria Sid et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Oxidant Mechanisms in Renal Injury and Disease

Brian B. Ratliff et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Review Pharmacology & Pharmacy

Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

Izaskun Buendia et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Editorial Material Urology & Nephrology

KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Acute Kidney Injury

Paul M. Palevsky et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2013)

Review Biochemistry & Molecular Biology

Glutathione synthesis

Shelly C. Lu

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

Article Agriculture, Multidisciplinary

Tyrosol Attenuates Ischemia-Reperfusion-Induced Kidney Injury via Inhibition of Inducible Nitric Oxide Synthase

Pengqi Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2013)

Review Urology & Nephrology

Role of Nrf2 in protection against acute kidney injury

Luke M. Shelton et al.

KIDNEY INTERNATIONAL (2013)

Article Pharmacology & Pharmacy

Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase

Lindsei K. Sarna et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2012)

Article Medical Laboratory Technology

A hazardous link between malnutrition, inflammation and oxidative stress in renal patients

Jelena Kotur-Stevuljevic et al.

CLINICAL BIOCHEMISTRY (2012)

Article Medicine, Research & Experimental

Cellular pathophysiology of ischemic acute kidney injury

Joseph V. Bonventre et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Medicine, General & Internal

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

Pablo E. Pergola et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Physiology

Folic acid supplementation inhibits NADPH oxidase-mediated superoxide anion production in the kidney

Sun-Young Hwang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)

Review Nutrition & Dietetics

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

Anne S. Tibbetts et al.

ANNUAL REVIEW OF NUTRITION, VOL 30 (2010)

Article Biochemistry & Molecular Biology

Ischemia/Reperfusion Reduces Transcription Factor Sp1-mediated Cystathionine β-Synthase Expression in the Kidney

Nan Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Peripheral Vascular Disease

Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options

M. P. C. Kao et al.

JOURNAL OF HUMAN HYPERTENSION (2010)

Article Urology & Nephrology

Specific nutritional problems in acute kidney injury, treated with non-dialysis and dialytic modalities

Enrico Fiaccadori et al.

CLINICAL KIDNEY JOURNAL (2010)

Article Urology & Nephrology

Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon

Sang Kyung Jo et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

Article Biochemistry & Molecular Biology

Hyperhomocysteinemia induces liver injury in rat: Protective effect of folic acid supplementation

Connie W. H. Woo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)

Article Transplantation

Impairment of glutathione biosynthetic pathway in uraemia and dialysis

MSS Alhamdani

NEPHROLOGY DIALYSIS TRANSPLANTATION (2005)