4.7 Review

The Vascular Niche for Adult Cardiac Progenitor Cells

Journal

ANTIOXIDANTS
Volume 11, Issue 5, Pages -

Publisher

MDPI
DOI: 10.3390/antiox11050882

Keywords

heart; cardiac turnover; endothelial cell; cardiac progenitor; stem cell; niche; vascular niche; Bmi1; polycomb; ROS

Funding

  1. Spanish Ministry of Science and Innovation (AEI/FEDER, UE) [RTI2018-097604-B-I00]
  2. Research Program of the Comunidad Autonoma de Madrid [S2017/BMD-3692]
  3. Instituto de Salud Carlos III [RETICS-RTI2018-097604-B-I00]
  4. Instituto de Salud Carlos III Spain

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Research on the interaction of adult cardiac progenitor cells with other cardiac cell populations can define the vascular cardiac stem cell niche, which is associated with low oxidative stress domains in vasculature, and manipulating this niche may offer new hope in the cardiac regeneration field.
Research on cardiac progenitor cell populations has generated expectations about their potential for cardiac regeneration capacity after acute myocardial infarction and during physiological aging; however, the endogenous capacity of the adult mammalian heart is limited. The modest efficacy of exogenous cell-based treatments can guide the development of new approaches that, alone or in combination, can be applied to boost clinical efficacy. The identification and manipulation of the adult stem cell environment, termed niche, will be critical for providing new evidence on adult stem cell populations and improving stem-cell-based therapies. Here, we review and discuss the state of our understanding of the interaction of adult cardiac progenitor cells with other cardiac cell populations, with a focus on the description of the B-CPC progenitor population (Bmi1+ cardiac progenitor cell), which is a strong candidate progenitor for all main cardiac cell lineages, both in the steady state and after cardiac damage. The set of all interactions should be able to define the vascular cardiac stem cell niche, which is associated with low oxidative stress domains in vasculature, and whose manipulation would offer new hope in the cardiac regeneration field.

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