The Antioxidant Effect of the Metal and Metal-Oxide Nanoparticles

Inorganic nanoparticles, such as CeO3, TiO2 and Fe3O4 could be served as a platform for their excellent performance in antioxidant effect. They may offer the feasibility to be further developed for their smaller and controllable sizes, flexibility to be modified, relative low toxicity as well as ease of preparation. In this work, the recent progress of these nanoparticles were illustrated, and the antioxidant mechanism of the inorganic nanoparticles were introduced, which mainly included antioxidant enzyme-mimetic activity and antioxidant ROS/RNS scavenging activity. The antioxidant effects and the applications of several nanoparticles, such as CeO3, Fe3O4, TiO2 and Se, are summarized in this paper. The potential toxicity of these nanoparticles both in vitro and in vivo was well studied for the further applications. Future directions of how to utilize these inorganic nanoparticles to be further applied in some fields, such as medicine, cosmetic and functional food additives were also investigated in this paper.

Automated summary

This paper illustrates the excellent performance of inorganic nanoparticles in antioxidant effect, including smaller and controllable sizes, flexibility to be modified, relative low toxicity and ease of preparation. The antioxidant mechanism of these nanoparticles, such as antioxidant enzyme-mimetic activity and antioxidant ROS/RNS scavenging activity, is introduced. The paper summarizes the antioxidant effects and applications of several nanoparticles and investigates the potential toxicity for further applications. Furthermore, the future directions of utilizing these inorganic nanoparticles in fields such as medicine, cosmetic and functional food additives are explored.