Journal
ANTIOXIDANTS
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/antiox11030493
Keywords
neurodegenerative disease; Rutaceae; phyto carbazole alkaloid; oxidative stress; neuroinflammation; Alzheimer's disease
Funding
- National Research Foundation of Korea
- Korean Government [2020R1A2B5B01002463, 2021R1A6A1A03038996]
- National Research Foundation of Korea [2020R1A2B5B01002463] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Plant-derived carbazole alkaloids are important compounds that have potential neuroprotective effects in ameliorating neurodegenerative diseases.
Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera Murraya, Clausena, Glycosmis, Micromelum and Zanthoxylum). Due to several significant biological activities, such as antitumor, antibacterial, antiviral, antidiabetic, anti-HIV and neuroprotective activities of the parent skeleton (3-methylcarbazole), carbazole alkaloids are recognized as an important class of potential therapeutic agents. Neurodegenerative diseases (NDs) may exhibit a vast range of conditions, affecting neurons primarily and leading ultimately to the progressive losses of normal motor and cognitive functions. The main pathophysiological indicators of NDs comprise increasing atypical protein folding, oxidative stresses, mitochondrial dysfunctions, deranged neurotransmissions and neuronal losses. Phyto-carbazole alkaloids can be investigated for exerting multitarget approaches to ameliorating NDs. This review presents a comprehensive evaluation of the available scientific literature on the neuroprotective mechanisms of phyto-carbazole alkaloids from the Rutaceae family in ameliorating NDs.
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