Journal
BIOMOLECULES
Volume 12, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/biom12050699
Keywords
cellular agriculture; stem cells; progenitor cells; tissue engineering; cultured meat; cultured seafood
Categories
Funding
- REALSENSE1: Monitoring of cell culture parameters using sensors for biomass and nutrients/metabolites in media: Lab-on-a-Chip (LOC) approach, Good Food Institute 2018 Competitive Grant Program and REALSENSE2: From Lab-On-A-Chip to Custom Bioreactor: Scale
- DAAD-Ministry of Education, Science and Technological Development of the Republic of Serbia bilateral collaboration project between Biosense Institute and Fraunhofer Institute for Process Engineering and Packaging IVV titled: Development of plant-based edi [872662]
- European Union's Horizon 2020 research and innovation program [739570]
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2022-14/200358]
- Manage Unit Competitiveness (PMUC) [C10F64005]
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Global food systems are facing pressure to provide enough food, especially protein-rich foods in times of crisis and inflation. Cultivated meat and seafood, obtained through cellular agriculture, are protein-rich alternatives. This review discusses vertebrate cell types and procedures relevant to cellular agriculture, as well as existing challenges and solutions.
Global food systems are under significant pressure to provide enough food, particularly protein-rich foods whose demand is on the rise in times of crisis and inflation, as presently existing due to post-COVID-19 pandemic effects and ongoing conflict in Ukraine and resulting in looming food insecurity, according to FAO. Cultivated meat (CM) and cultivated seafood (CS) are protein-rich alternatives for traditional meat and fish that are obtained via cellular agriculture (CA) i.e., tissue engineering for food applications. Stem and progenitor cells are the building blocks and starting point for any CA bioprocess. This review presents CA-relevant vertebrate cell types and procedures needed for their myogenic and adipogenic differentiation since muscle and fat tissue are the primary target tissues for CM/CS production. The review also describes existing challenges, such as a need for immortalized cell lines, or physical and biochemical parameters needed for enhanced meat/fat culture efficiency and ways to address them.
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