Journal
BIOMOLECULES
Volume 12, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/biom12050697
Keywords
airways; allergy; CD73; ecto-5 '-nucleotidase; mast cells; hyperresponsiveness; B cells; CD23; sensitization
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Funding
- University of Naples Federico II [DR 409]
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The study demonstrates the important role of CD73 in allergic asthma, with mice lacking CD73 showing different responses to allergens compared to wild type mice, suggesting CD73 as a potential therapeutic target for allergic asthma.
Ecto-5'-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions. We previously demonstrated that CD73 is required for the assessment of a controlled allergic sensitization, in mice. Here, we evaluated the response to aerosolized allergen of female-sensitized mice lacking CD73 in comparison with their wild type counterpart. Results obtained show, in mice lacking CD73, the absence of airway hyperreactivity in response to an allergen challenge, paralleled by reduced airway CD23(+)B cells and IL4(+)T cells pulmonary accumulation together with reduced mast cells accumulation and degranulation. Our findings indicate CD73 as a potential therapeutic target for allergic asthma.
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