MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms

beta-cells are insulin-producing cells in the pancreas that maintain euglycemic conditions. Pancreatic beta-cell maturity and function are regulated by a variety of transcription factors that enable the adequate expression of the cellular machinery involved in nutrient sensing and commensurate insulin secretion. One of the key factors in this regulation is MAF bZIP transcription factor A (MafA). MafA expression is decreased in type 2 diabetes, contributing to beta-cell dysfunction and disease progression. The molecular biology underlying MafA is complex, with numerous transcriptional and post-translational regulatory nodes. Understanding these complexities may uncover potential therapeutic targets to ameliorate beta-cell dysfunction. This article will summarize the role of MafA in normal beta-cell function and disease, with a special focus on known transcriptional and post-translational regulators of MafA expression

Automated summary

The expression of MafA, a key transcription factor, is decreased in type 2 diabetes, leading to beta-cell dysfunction. Understanding the regulatory factors of MafA expression may help identify potential therapeutic targets for improving beta-cell function.