Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review

Current evidence pinpoints that the variability in periodontitis traits in humans may be attributable to genetic factors. Different allelic variants can result in alterations in tissue structure, antibody responses and inflammatory mediators. Consequently, genetic variations may act as protective or risk factors for periodontal diseases. A number of features of the inflammatory and immune response that seem to play a role in the development of periodontitis have a clearly established genetic basis. Identifying genes that contribute to the pathogenesis of periodontitis may be utilized for risk assessment in both aggressive and chronic periodontitis. The aim of this narrative review is to summarize the role of polymorphisms in genes involved in inflammation and periodontitis, including cellular receptors, tissue compatibility antigens, antibodies and cytokines.

Automated summary

Genetic factors play a significant role in the variability of periodontitis traits in humans. Different allelic variants can affect tissue structure, antibody responses, and inflammatory mediators, acting as protective or risk factors for periodontal diseases. Identifying genes associated with periodontitis can be used for risk assessment.