Journal
VACCINES
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/vaccines10040508
Keywords
SARS-CoV-2; COVID-19 vaccine; neutralizing antibodies; delta variant
Categories
Funding
- German Federal Ministry of Education and Research [01KI20703]
- CureVac AG
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A third dose of CVnCoV vaccine can effectively boost neutralizing antibody responses against both wild-type and Delta variant of SARS-CoV-2, regardless of age or previous exposure to the virus. This indicates that the first two doses have induced immune memory, and a third dose is beneficial for enhancing immune response.
A third dose of CVnCoV, a former candidate mRNA vaccine against SARS-CoV-2, was previously shown to boost neutralizing antibody responses against SARS-CoV-2 wild-type in adults aged 18-60 and >60 years in a phase 2a clinical study. In the present study, we report the neutralizing antibody responses to a wild-type and a variant of concern, Delta, after a third dose of the vaccine on day (D)57 and D180. Neutralization activity was assessed using a microneutralization assay. Comparable levels of neutralizing antibodies against the wild-type and Delta were induced. These were higher than those observed after the first two doses, irrespective of age or pre-SARS-CoV-2-exposure status, indicating that the first two doses induced immune memory. Four weeks after the third dose on D180, the neutralizing titers for wild-type and Delta were two-fold higher in younger participants than in older participants; seroconversion rates were 100% for wild-type and Delta in the younger group and for Delta in the older group. A third CVnCoV dose induced similar levels of neutralizing responses against wild-type virus and the Delta variant in both naive and pre-exposed participants, aligning with current knowledge from licensed COVID-19 vaccines that a third dose is beneficial against SARS-CoV-2 variants.
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