Journal
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.860305
Keywords
trachea; vivo; multispectral; imaging; optoacoustic tomography
Funding
- Doctoral Innovative Talents Program of Chongqing University of Posts and Telecommunications [BYJS202117]
- Chongqing Education Commission, Youth Fund [KJQN20200607]
- program of Chengdu Fifth peoples hospital Fund [2021123019]
- Xinglin Scholars research program [YYZX2021037]
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This study evaluated the feasibility of using photoacoustic tomography (PAT) and multispectral optoacoustic tomography (MSOT) for detecting histology in a rabbit tracheal stenosis model. The results showed that PAT/MSOT can be used to evaluate tracheal structure and function in vivo.
Objective: Photoacoustic tomography (PAT) and multispectral optoacoustic tomography (MSOT) are evolving technologies that are capable of delivering real-time, high-resolution images of tissues. The purpose of this study was to evaluate the feasibility of using PAT and MSOT for detecting histology in a rabbit tracheal stenosis model.\nMethod: A total of 12 rabbits (9 stenosis and three control) were randomly divided into four groups (A, B, C and D). Each group consisted of three rabbits, which were staged at the first, fourth, and eighth weeks of stenosis progression, respectively. PAT/MSOT images and corresponding histology from these experimental animals were compared, for analyzing the morphologic features and quantitative tracheal measurements in different tracheal stenosis stage.Result: Both the PAT images and corresponding histology indicated the most severe degree of stenosis in group C. MSOT images indicated notable differences in tracheal contents of group B and D.Conclusion: This study suggests that PAT/MSOT are potentially valuable non-invasive modality which are capable of evaluating tracheal structure and function in vivo.
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