4.7 Article

Layered Double Hydroxides-Loaded Sorafenib Inhibit Hepatic Stellate Cells Proliferation and Activation In Vitro and Reduce Fibrosis In Vivo

Related references

Note: Only part of the references are listed.
Review Environmental Sciences

Layered double hydroxides and LDH-derived materials in chosen environmental applications: a review

Dylan Chaillot et al.

Summary: Layered double hydroxides and related materials play a key role in reducing environmental impact, with efficient synthesis and tunable properties. Their physical and structural properties make them suitable for environmental applications such as adsorption of pollutants and hydrogen production.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

Article Plant Sciences

Xiaoyaosan decoction alleviated rat liver fibrosis via the TGFβ/Smad and Akt/FoxO3 signaling pathways based on network pharmacology analysis

Yuan Zhou et al.

Summary: This study aimed to investigate the anti-fibrosis effect of Xiaoyaosan decoction (XYS) and explore the molecular mechanisms using network pharmacology and transcriptomic technologies. The results showed that XYS significantly improved liver function and alleviated fibrotic changes, possibly through the TGFβ1/Smad and Akt/FoxO signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Nanoscience & Nanotechnology

Albumin-stabilized layered double hydroxide nanoparticles synergized combination chemotherapy for colorectal cancer treatment

Li Li et al.

Summary: The study presents a novel approach using albumin-stabilized layered double hydroxide nanoparticles to simultaneously load and deliver two anti-tumor drugs for colorectal cancer treatment, showing promising therapeutic effectiveness without detectable side effects.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

Article Pharmacology & Pharmacy

Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis

Donghao Gan et al.

Summary: Clinical studies have shown that pirfenidone effectively relieves joint pain in rheumatoid arthritis patients. This study investigated the repurposing of pirfenidone for RA treatment and explored its anti-rheumatic mechanisms. Through in vivo and in vitro models, the study suggested that pirfenidone may alleviate pathological changes in RA by inhibiting inflammation and angiogenesis through multiple pathways such as JAK2/STAT3 and Akt.

FRONTIERS IN PHARMACOLOGY (2021)

Article Cell Biology

Germacrone improves liver fibrosis by regulating the PI3K/AKT/mTOR signalling pathway

De Ji et al.

Summary: Liver fibrosis is a major threat to public health due to limited treatment options, but germacrone (GM) has shown promising effects in improving liver fibrosis in rat models by inhibiting HSCs growth and EMT progression via the PI3K/AKT/mTOR signaling pathway. GM also improved histological damage and liver enzyme levels, highlighting its potential as a therapeutic agent for liver fibrosis.

CELL BIOLOGY INTERNATIONAL (2021)

Article Pharmacology & Pharmacy

TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis

Hongrui Guo et al.

Summary: Copper is an essential trace element for living organisms, but over-exposure can lead to adverse health effects. Research found that copper sulfate treatment induced pulmonary fibrosis in mice, activating multiple signaling pathways and causing epithelial-mesenchymal transition. This study reveals the mechanism of copper-induced pulmonary toxicity through EMT induced by TGF-beta 1/Smad and MAPKs pathways.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Optimally designed theranostic system based folic acids and chitosan as a promising mucoadhesive delivery system for encapsulating curcumin LbL nano-template against invasiveness of breast cancer

Nemany A. N. Hanafy

Summary: Curcumin, a potential candidate in cancer therapy, can be improved in its accumulation and release inside cancer cells by functionalized multi-layered polyelectrolyte capsules.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Gastroenterology & Hepatology

Collagen biology and non-invasive biomarkers of liver fibrosis

Morten A. Karsdal et al.

LIVER INTERNATIONAL (2020)

Article Pharmacology & Pharmacy

Encapsulation of curcumin into layered double hydroxides improve their anticancer and antiparasitic activity

Filiberto Gutierrez-Gutierrez et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)

Article Materials Science, Biomaterials

Mucoadhesive curcumin crosslinked carboxy methyl cellulose might increase inhibitory efficiency for liver cancer treatment

Nemany A. N. Hanafy et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Gastroenterology & Hepatology

MicroRNA-101 suppresses liver fibrosis by downregulating PI3K/Akt/mTOR signaling pathway

Yang Lei et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2019)

Review Chemistry, Multidisciplinary

Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System

Nemany A. N. Hanafy et al.

APPLIED SCIENCES-BASEL (2019)

Article Materials Science, Biomaterials

Layered Double Hydroxides Are Promising Nanomaterials for Tissue Bioengineering Application

Celio Jr da Costa Fernandes et al.

ADVANCED BIOSYSTEMS (2019)

Article Biochemistry & Molecular Biology

New insights into TGF-β/Smad signaling in tissue fibrosis

He-He Hu et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2018)

Review Nanoscience & Nanotechnology

Nanoparticles for the treatment of liver fibrosis

Suchithra Poilil Surendran et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Review Gastroenterology & Hepatology

Mechanisms of hepatic stellate cell activation

Takuma Tsuchida et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Review Medicine, Research & Experimental

Sorafenib: A potential therapeutic drug for hepatic fibrosis and its outcomes

Rui Ma et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Oncology

Hepatocellular carcinoma (HCC): beyond sorafenib-chemotherapy

Dae Won Kim et al.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2017)

Review Cell Biology

Epithelial-mesenchymal transition in tissue repair and fibrosis

Rivka C. Stone et al.

CELL AND TISSUE RESEARCH (2016)

Article Biochemistry & Molecular Biology

The PI3K AKT pathway in the pathogenesis of prostate cancer

Xiaofei Wen

Frontiers in Bioscience-Landmark (2016)

Article Toxicology

Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis

Shu Dong et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2016)

Review Gastroenterology & Hepatology

Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

Chong-Yang Zhang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Article Medicine, Research & Experimental

Epithelial-mesenchymal transition in liver fibrosis

Ya-Lei Zhao et al.

BIOMEDICAL REPORTS (2016)

Article Gastroenterology & Hepatology

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

Yan Wang et al.

JOURNAL OF HEPATOLOGY (2010)

Article Gastroenterology & Hepatology

The role of Smad3 in mediating mouse hepatic stellate cell activation

B Schnabl et al.

HEPATOLOGY (2001)