4.7 Review

Decellularization Strategies for Regenerating Cardiac and Skeletal Muscle Tissues

Related references

Note: Only part of the references are listed.
Article Cell & Tissue Engineering

Myocardial repair of bioengineered cardiac patches with decellularized placental scaffold and human-induced pluripotent stem cells in a rat model of myocardial infarction

Yu Jiang et al.

Summary: The study found that a decellularized placenta scaffold contains multiple growth and angiogenic factors that enhance the maturation and survival of seeded hiPSC-CMs. Transplantation of a bioengineered cardiac patch (BCP) is superior to using placenta or hiPSC-CMs alone in reducing infarct size and improving cell retention and neovascularization.

STEM CELL RESEARCH & THERAPY (2021)

Article Cardiac & Cardiovascular Systems

Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG

Xinming Wang et al.

Summary: The study found that injectable fetal-derived dECM hydrogel treatment can reduce fibroblast activation and contractility, and alleviate stiffness-mediated fibroblast activation in stiffened tissues. The anti-fibrotic effect of this hydrogel is most pronounced at the highest stiffness levels.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

Article Chemistry, Multidisciplinary

Functional Skeletal Muscle Regeneration with Thermally Drawn Porous Fibers and Reprogrammed Muscle Progenitors for Volumetric Muscle Injury

Yoonhee Jin et al.

Summary: The passage highlights the need for interventions to induce functional skeletal muscle restoration, with a focus on tissue-engineered muscle constructs. It mentions the current challenges in reliable cell sources and tissue scaffold engineering for tissue-engineering treatments.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Reconstruction of Muscle Fascicle-Like Tissues by Anisotropic 3D Patterning

Yoonhee Jin et al.

Summary: This study demonstrates a biomimetic approach for generating functional skeletal muscle fascicle-like tissues by recapitulating 3D muscle-like cellular and extracellular organization. The anisotropic 3D alignment of muscle extracellular matrix nanofibrils supports de novo muscle regeneration and induces functional restoration of injured muscles, showing the clinical potential of artificial muscle constructs in regenerative medicine.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Engineering, Biomedical

Tunable electroconductive decellularized extracellular matrix hydrogels for engineering human cardiac microphysiological systems

Jonathan H. Tsui et al.

Summary: Hybrid hydrogels composed of decellularized porcine myocardial extracellular matrix (dECM) and reduced graphene oxide (rGO) were developed to improve the functionality of cardiomyocytes. These hydrogels can also be used as bioinks to print cardiac tissues in a high-throughput manner. Modulating the composition and properties of the materials can enhance the electrophysiological function of cardiac tissues.

BIOMATERIALS (2021)

Article Engineering, Biomedical

Bioactive Decellularized Extracellular Matrix Derived from 3D Stem Cell Spheroids under Macromolecular Crowding Serves as a Scaffold for Tissue Engineering

Cheng-En Chiang et al.

Summary: The study developed 3D decellularized ECM scaffolds from MSC spheroids, which preserved structural ECM components and growth factors, resulting in enhanced proangiogenic activity. These scaffolds could be populated by endothelial cells to build larger cell-carrying constructs, enhancing intrinsic revascularization in vivo.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Biochemistry & Molecular Biology

Biohybrid oxidized alginate/myocardial extracellular matrix injectable hydrogels with improved electromechanical properties for cardiac tissue engineering

Ali Mousavi et al.

Summary: The study presents the optimization of a newly-developed hydrogel derived from biological macromolecules with improved mechanical properties and electrical conductivity for cardiac tissue engineering. Functionalized reduced graphene oxide was added to enhance the electromechanical properties of the hydrogel, showing potential for providing a desirable platform in this field.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Multidisciplinary Sciences

Engineering aligned human cardiac muscle using developmentally inspired fibronectin micropatterns

Ivan Batalov et al.

Summary: Engineered cardiac two-dimensional tissues with biomimetic micropatterns provide insights into the interactions between cardiomyocytes and cell-ECM, driving cell alignment and organization. Experimental findings suggest that cell density, N-cadherin, involvement of cardiac fibroblasts, and T3 hormone treatment all influence cardiomyocyte alignment. These results are not only significant for engineering anisotropic cardiac tissues in vitro, but also provide valuable insights into factors influencing cardiogenesis in vivo.

SCIENTIFIC REPORTS (2021)

Review Biotechnology & Applied Microbiology

Accounting for Material Changes in Decellularized Tissue with Underutilized Methodologies

Ryan A. Behmer Hansen et al.

Summary: Tissue decellularization is a key method in tissue engineering research for generating natural scaffolds for cell transplantation and organ therapy. Various techniques preserve the molecular and microstructural features of tissues. Beyond structural and molecular cues, consideration of mechanical and material properties is important.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Physics, Applied

Self-aligned myofibers in 3D bioprinted extracellular matrix-based construct accelerate skeletal muscle function restoration

Hyeongjin Lee et al.

Summary: By combining biochemical and topographic cues, 3D bioprinting technology can effectively restore muscle function and reconstruct extensive muscle defects.

APPLIED PHYSICS REVIEWS (2021)

Article Food Science & Technology

Decellularized spinach: An edible scaffold for laboratory-grown meat

Jordan D. Jones et al.

Summary: By 2050, there may not be enough land suitable for agriculture globally and cellular agriculture offers a potential solution to produce edible meat. This study demonstrates that decellularized spinach leaves can serve as an edible scaffold for the growth of animal muscle cells, potentially accelerating the development of lab-grown meat.

FOOD BIOSCIENCE (2021)

Review Biochemistry & Molecular Biology

The Emerging Role of Decellularized Plant-Based Scaffolds as a New Biomaterial

Ashlee F. Harris et al.

Summary: Decellularization technology of plant-based biomaterials has significantly advanced in recent years, offering low-cost, accessible, and sustainable options for generating tissue-engineered substitutes or in vitro cellular models. These scaffolds possess unique structural and mechanical properties, making them suitable for a wide range of applications in biomedical research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Food Science & Technology

Global greenhouse gas emissions from animal-based foods are twice those of plant-based foods

Xiaoming Xu et al.

Summary: This study provides a detailed account of greenhouse gas emissions from plant- and animal-based foods worldwide, with agriculture and land use identified as major sources of emissions. Rice and beef were found to be the largest contributing commodities, with global emissions primarily coming from the production of animal-based food.

NATURE FOOD (2021)

Article Multidisciplinary Sciences

Effects of chemical and physical methods on decellularization of murine skeletal muscles

Carla M. F. C. Miranda et al.

Summary: Freezing samples before decellularization and starting the process with 1% SDS solution showed optimal results in removing cells and DNA content, while preserving the ultrastructure and composition of the matrix.

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2021)

Article Polymer Science

Tunable Human Myocardium Derived Decellularized Extracellular Matrix for 3D Bioprinting and Cardiac Tissue Engineering

Gozde Basara et al.

Summary: This study focused on developing bioinks with decellularized human heart ECM and gelatin methacryloyl or gelatin methacryloyl-methacrylated hyaluronic acid hydrogels, dual crosslinked with UV light and microbial transglutaminase, to achieve improved mechanical properties for 3D tissue constructs in cardiac tissue engineering. The bioinks showed compatibility with human induced pluripotent stem cell derived cardiomyocytes and human cardiac fibroblasts, leading to tissue-like beating constructs with striated sarcomeric alpha-actinin and connexin 43 expression. The order of magnitude difference in elastic modulus between hydrogel composites offers applications in in vitro modeling of the myocardial infarct boundary, as demonstrated by creating an infarct boundary region with controlled mechanical properties and cellular content through bioink printing.
Article Engineering, Biomedical

Aligned nanofibers of decellularized muscle extracellular matrix for volumetric muscle loss

Krishna H. Patel et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2020)

Review Biochemistry & Molecular Biology

3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate

Julien Nicolas et al.

BIOMACROMOLECULES (2020)

Review Pharmacology & Pharmacy

Proteoglycans in Biomedicine: Resurgence of an Underexploited Class of ECM Molecules

Tanaya Walimbe et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Engineering, Biomedical

Creation of a contractile biomaterial from a decellularized spinach leaf without ECM protein coating: An in vitro study

Emily R. Robbins et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

Article Materials Science, Biomaterials

Engineering Aligned Skeletal Muscle Tissue Using Decellularized Plant-Derived Scaffolds

Ya-Wen Cheng et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Article Cell & Tissue Engineering

Decellularized skeletal muscles display neurotrophic effects inthree-dimensionalorganotypic cultures

Paolo Raffa et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

Article Cell & Tissue Engineering

Tissue-engineered human embryonic stem cell-containing cardiac patches: evaluating recellularization of decellularized matrix

Camila Hochman-Mendez et al.

JOURNAL OF TISSUE ENGINEERING (2020)

Review Biotechnology & Applied Microbiology

Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications

Taylor Cook Suh et al.

BIOENGINEERING-BASEL (2020)

Article Cell & Tissue Engineering

Fabrication and Characterization of Electrospun Decellularized Muscle-Derived Scaffolds

Mollie M. Smoak et al.

TISSUE ENGINEERING PART C-METHODS (2019)

Article Engineering, Biomedical

A bioartificial rat heart tissue: Perfusion decellularization and characterization

Busra Ozlu et al.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2019)

Article Cell & Tissue Engineering

Decellularized extracellular matrix gelloids support mesenchymal stem cell growth and function in vitro

Muhamed Talovic et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

Review Materials Science, Biomaterials

Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges

K. C. Pawan et al.

REGENERATIVE BIOMATERIALS (2019)

Review Biochemistry & Molecular Biology

Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review

Kevin Dzobo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Engineering, Biomedical

3D-printing porosity: A new approach to creating elevated porosity materials and structures

A. E. Jakus et al.

ACTA BIOMATERIALIA (2018)

Editorial Material Cell & Tissue Engineering

Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics

Thomas A. Rando et al.

CELL STEM CELL (2018)

Review Biochemical Research Methods

Proteomic analysis of the cardiac extracellular matrix: clinical research applications

Merry L. Lindsey et al.

EXPERT REVIEW OF PROTEOMICS (2018)

Article Cardiac & Cardiovascular Systems

Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues

Andrea Leonard et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

Review Pharmacology & Pharmacy

Biological responses to immobilized microscale and nanoscale surface topographies

Shelby A. Skoog et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Article Multidisciplinary Sciences

Decellularised skeletal muscles allow functional muscle regeneration by promoting host cell migration

Anna Urciuolo et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

A Thin Layer of Decellularized Porcine Myocardium for Cell Delivery

Mickey Shah et al.

SCIENTIFIC REPORTS (2018)

Article Engineering, Biomedical

A Bioprinted Cardiac Patch Composed of Cardiac-Specific Extracellular Matrix and Progenitor Cells for Heart Repair

Donald Bejleri et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Article Biotechnology & Applied Microbiology

Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications

Anna Gilpin et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Review Physics, Multidisciplinary

Collagen Type I as a Ligand for Receptor-Mediated Signaling

Iris Boraschi-Diaz et al.

FRONTIERS IN PHYSICS (2017)

Article Engineering, Biomedical

Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds

Joshua R. Gershlak et al.

BIOMATERIALS (2017)

Article Engineering, Biomedical

Inverted orientation improves decellularization of whole porcine hearts

Po-Feng Lee et al.

ACTA BIOMATERIALIA (2017)

Article Chemistry, Multidisciplinary

Nanoscale Patterning of Extracellular Matrix Alters Endothelial Function under Shear Stress

Karina H. Nakayama et al.

NANO LETTERS (2016)

Article Biochemical Research Methods

Quantification of decellularized human myocardial matrix: A comparison of six patients

Todd D. Johnson et al.

PROTEOMICS CLINICAL APPLICATIONS (2016)

Review Biochemical Research Methods

Cardiac extracellular matrix proteomics: Challenges, techniques, and clinical implications

Chia Wei Chang et al.

PROTEOMICS CLINICAL APPLICATIONS (2016)

Article Engineering, Biomedical

Natural myocardial ECM patch drives cardiac progenitor based restoration even after scarring

Udi Sarig et al.

ACTA BIOMATERIALIA (2016)

Review Chemistry, Multidisciplinary

Anisotropic Materials for Skeletal-Muscle-Tissue Engineering

Soumen Jana et al.

ADVANCED MATERIALS (2016)

Article Biotechnology & Applied Microbiology

Development of an Infusion Bioreactor for the Accelerated Preparation of Decellularized Skeletal Muscle Scaffolds

Benjamin M. Kasukonis et al.

BIOTECHNOLOGY PROGRESS (2016)

Article Multidisciplinary Sciences

Anisotropic engineered heart tissue made from laser-cut decellularized myocardium

Jonas Schwan et al.

SCIENTIFIC REPORTS (2016)

Article Engineering, Biomedical

3D Cell Printing of Functional Skeletal Muscle Constructs Using Skeletal Muscle-Derived Bioink

Yeong-Jin Choi et al.

ADVANCED HEALTHCARE MATERIALS (2016)

Article Biochemistry & Molecular Biology

Decellularized Human Skeletal Muscle as Biologic Scaffold for Reconstructive Surgery

Andrea Porzionato et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Cell & Tissue Engineering

Bilayered vascular graft derived from human induced pluripotent stem cells with biomimetic structure and function

Karina H. Nakayama et al.

REGENERATIVE MEDICINE (2015)

Review Biochemical Research Methods

Recent advances in 3D printing of biomaterials

Helena N. Chia et al.

JOURNAL OF BIOLOGICAL ENGINEERING (2015)

Article Multidisciplinary Sciences

Optimizing Recellularization of Whole Decellularized Heart Extracellular Matrix

Matthew J. Robertson et al.

PLOS ONE (2014)

Review Cell & Tissue Engineering

Skeletal Muscle Tissue Engineering: Methods to Form Skeletal Myotubes and Their Applications

Serge Ostrovidov et al.

TISSUE ENGINEERING PART B-REVIEWS (2014)

Article Biochemistry & Molecular Biology

An Alternative Approach to Decellularize Whole Porcine Heart

Ketaki Methe et al.

BIORESEARCH OPEN ACCESS (2014)

Review Biophysics

The Mechanism of Detergent Solubilization of Lipid Bilayers

Dov Lichtenberg et al.

BIOPHYSICAL JOURNAL (2013)

Article Cardiac & Cardiovascular Systems

Normal Ranges of Left Ventricular Strain: A Meta-Analysis

Teerapat Yingchoncharoen et al.

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY (2013)

Article Multidisciplinary Sciences

Immunomodulatory effect of a decellularized skeletal muscle scaffold in a discordant xenotransplantation model

Jonathan M. Fishman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell & Tissue Engineering

Optical Imaging Predicts Mechanical Properties During Decellularization of Cardiac Tissue

Nick Merna et al.

TISSUE ENGINEERING PART C-METHODS (2013)

Article Otorhinolaryngology

Decellularized Rabbit Cricoarytenoid Dorsalis Muscle for Laryngeal Regeneration

Jonathan M. Fishman et al.

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY (2012)

Article Engineering, Biomedical

Biologic scaffold composed of skeletal muscle extracellular matrix

Matthew T. Wolf et al.

BIOMATERIALS (2012)

Article Engineering, Biomedical

Consequences of ineffective decellularization of biologic scaffolds on the host response

Timothy J. Keane et al.

BIOMATERIALS (2012)

Review Dermatology

Growth Factor-Extracellular Matrix Interactions Regulate Wound Repair

Traci A. Wilgus

ADVANCES IN WOUND CARE (2012)

Article Engineering, Biomedical

Advantages of RGD peptides for directing cell association with biomaterials

Susan L. Bellis

BIOMATERIALS (2011)

Review Engineering, Biomedical

An overview of tissue and whole organ decellularization processes

Peter M. Crapo et al.

BIOMATERIALS (2011)

Article Cell & Tissue Engineering

Method for Decellularizing Skeletal Muscle Without Detergents or Proteolytic Enzymes

Allison R. Gillies et al.

TISSUE ENGINEERING PART C-METHODS (2011)

Article Cell & Tissue Engineering

A Whole-Organ Regenerative Medicine Approach for Liver Replacement

Alejandro Soto-Gutierrez et al.

TISSUE ENGINEERING PART C-METHODS (2011)

Article Cell & Tissue Engineering

Preparation of Cardiac Extracellular Matrix from an Intact Porcine Heart

John M. Wainwright et al.

TISSUE ENGINEERING PART C-METHODS (2010)

Article Surgery

Quantification of DNA in Biologic Scaffold Materials

Thomas W. Gilbert et al.

JOURNAL OF SURGICAL RESEARCH (2009)

Article Biochemistry & Molecular Biology

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

Harald C. Ott et al.

NATURE MEDICINE (2008)

Article Engineering, Biomedical

Matrix stiffness affects spontaneous contraction of cardiomyocytes cultured within a PEGylated fibrinogen biomaterial

Keren Shapira-Schweitzer et al.

ACTA BIOMATERIALIA (2007)