Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.874840
Keywords
mechanobiology; classical Ehlers-Danlos syndrome; hypermobile Ehlers-Danlos Syndrome; collagen V; extracellular matrix; stiffness; mast cell degranulation
Categories
Funding
- NIH [1R15GM135806-01]
- Michigan Tech's Research Excellence Fund (REF) award
- Portage Health Foundation's Undergraduate Research Internship Program (URIP)
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Ehlers-Danlos Syndromes (EDS) are a group of connective tissue disorders characterized by skin stretchability, joint hypermobility, and instability, possibly associated with reduced tissue stiffness. Comorbidities include mast cell activation syndrome and impaired wound healing, and potential mechanobiological mechanisms need further investigation.
Ehlers-Danlos Syndromes (EDSs) are a group of connective tissue disorders, characterized by skin stretchability, joint hypermobility and instability. Mechanically, various tissues from EDS patients exhibit lowered elastic modulus and lowered ultimate strength. This change in mechanics has been associated with EDS symptoms. However, recent evidence points toward a possibility that the comorbidities of EDS could be also associated with reduced tissue stiffness. In this review, we focus on mast cell activation syndrome and impaired wound healing, comorbidities associated with the classical type (cEDS) and the hypermobile type (hEDS), respectively, and discuss potential mechanobiological pathways involved in the comorbidities.
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