Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.896305
Keywords
membrane-bound organelles; membrane-less condensates; stress granules; protein aggregates; phase separation
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Funding
- NIH Office of the Director [DP5OD024598]
- National Institute on Aging [R03AG070478]
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A major recent advance in cell biology is the understanding of the mechanisms and dynamics of biogenesis of membrane-less condensates. These condensates interact with membrane-bound organelles and are regulated by cellular signaling, metabolic states, and proteostasis network.
A major recent advance in cell biology is the mechanistic and kinetic understanding of biogenesis of many membrane-less condensates. As membrane-less condensates and membrane-bound organelles are two major approaches used by the eukaryotic cells to organize cellular contents, it is not surprising that these membrane-less condensates interact with the membrane-bound organelles and are dynamically regulated by the cellular signaling, metabolic states, and proteostasis network. In this review, I will discuss recent progress in the biogenesis of membrane-less condensates and their connections with well-studied membrane-bound organelles. Future work will reveal the molecular and functional connectome among different condensates and membrane-bound organelles.
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