4.7 Review

Plasmalogens and Photooxidative Stress Signaling in Myxobacteria, and How it Unmasked CarF/TMEM189 as the Δ1′-Desaturase PEDS1 for Human Plasmalogen Biosynthesis

Related references

Note: Only part of the references are listed.
Article Microbiology

Coenzyme B-12-dependent and independent photoregulation of carotenogenesis across Myxococcales

Ricardo Perez-Castano et al.

Summary: This study investigates the light-induced carotenogenesis in Myxococcus xanthus and explores its regulation mechanisms. The B-12-based CarH repressor and photoreceptor are found to control the carotenogenesis, along with a separate pathway involving singlet oxygen and various other proteins. Comparative analyses across different Myxococcales genomes reveal the conservation of carotenogenic genes and the presence of CarA and its associated factors exclusively in the suborder Cystobacterineae. The study also reveals a plastic CarH operator design and DNA binding across Myxococcales. Overall, this research provides new insights into photoregulated carotenogenesis and establishes its prevalence and evolution in myxobacteria.

ENVIRONMENTAL MICROBIOLOGY (2022)

Article Biochemistry & Molecular Biology

Essential role of a conserved aspartate for the enzymatic activity of plasmanylethanolamine desaturase

Ernst R. Werner et al.

Summary: Plasmalogens are abundant glycerophospholipids in mammals, and the final enzyme of their biosynthesis, PEDS1, was found to be related to plant desaturases. In this study, mutation of specific amino acid residues of murine PEDS1 revealed that aspartate 100 and phenylalanine 118 are essential for PEDS1 activity, with aspartate 100 potentially interacting with histidine 96 and phenylalanine 118 interacting with histidine 187.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Article Biochemistry & Molecular Biology

Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in Clostridium perfringens

David R. Jackson et al.

Summary: Plasmalogens, vinyl ether-containing lipids, can be produced by both mammals and bacteria. While the aerobic biosynthetic pathway is known, a new anaerobic pathway for plasmalogen production has been discovered in the bacterium Clostridium perfringens. Heterologous expression of the pis operon from C. perfringens in E. coli resulted in the production of plasmalogens, indicating the potential for application in biotechnology.

ACS CHEMICAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Bioactive Ether Lipids: Primordial Modulators of Cellular Signaling

Nikhil Rangholia et al.

Summary: This review highlights the importance of lipids in cellular membranes and their role as signaling molecules. It specifically focuses on ether lipids, their biosynthesis in mammalian cells, the roles of selected glycerolipids and glycerophospholipids in signal transduction, and the potential therapeutic contributions of synthetic ether lipids to cancer treatment.

METABOLITES (2021)

Article Biochemistry & Molecular Biology

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis

Weiwei Cui et al.

Summary: Ferroptosis is primarily induced by peroxidation of long-chain PUFA, but the role of SFA remains unclear. The study identified FAR1 as a key factor in SFA-mediated ferroptosis, involved in the synthesis of alkyl-ether lipids and plasmalogens, revealing a new pathway for ferroptosis.

CELL DEATH AND DIFFERENTIATION (2021)

Review Biochemistry & Molecular Biology

Extracytoplasmic Function σ Factors as Tools for Coordinating Stress Responses

Ruben de Dios et al.

Summary: The bacterial core RNA polymerase can interact with different sigma factors to form a variety of holoenzymes, aiding in coordinating gene expression. Extracytoplasmic function sigma factors (ECFs) play a role in stress responses and have been classified into 157 groups based on their phylogenetic relationships and genomic context, showcasing their diversity. This study focuses on 55 experimentally studied ECF groups, categorizing them into two broad classes of stress responses, and discusses the mechanisms controlling their production and activity for a functional stress response.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Genetics & Heredity

A genome-wide atlas of co-essential modules assigns function to uncharacterized genes

Michael Wainberg et al.

Summary: A new statistical method has been developed to robustly identify gene co-essentiality and yield a genome-wide set of functional modules, predicting the functions of 108 uncharacterized genes effectively.

NATURE GENETICS (2021)

Review Microbiology

Light-Triggered Carotenogenesis in Myxococcus xanthus: New Paradigms in Photosensory Signaling, Transduction and Gene Regulation

S. Padmanabhan et al.

Summary: Myxobacteria are Gram-negative delta-proteobacteria that synthesize carotenoids to protect cells from oxidative stress induced by light exposure. Research on light sensing, signal transduction, and gene regulation in Myxococcus xanthus has led to the discovery of new paradigms and novel protein families, shedding light on the molecular mechanisms underlying light-dependent signaling and carotenoid biosynthesis regulation.

MICROORGANISMS (2021)

Article Multidisciplinary Sciences

Highly accurate protein structure prediction for the human proteome

Kathryn Tunyasuvunakool et al.

Summary: Using the AlphaFold method, the structural coverage of the proteome has been significantly expanded, covering 98.5% of human proteins with 58% of residues having confident predictions and 36% having very high confidence. Introducing new metrics to interpret the dataset and identify disordered regions, this study aims to provide high-quality predictions for generating biological hypotheses.

NATURE (2021)

Article Multidisciplinary Sciences

Evolution of bacterial steroid biosynthesis and its impact on eukaryogenesis

Yosuke Hoshino et al.

Summary: Steroids play essential roles in eukaryotic endocytosis by regulating membrane properties. The evolution of eukaryotic cellular membranes is more related to bacteria rather than archaea. The transfer of key genes for steroid biosynthesis to eukaryotes may have been mediated by deltaproteobacteria. Resurrected steroid biosynthesis enzymes suggest similarities in the pathway between early eukaryotes and modern plants, with the requirement of molecular oxygen for establishing the modern eukaryotic cellular membrane.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Biochemistry & Molecular Biology

Plasmalogens - Ubiquitous molecules occurring widely, from anaerobic bacteria to humans

Milada Vitova et al.

Summary: Plasmalogens are a group of lipids mainly found in cell membranes that can protect cells from damage by reactive oxygen species and are implicated as signaling molecules and modulators of membrane dynamics. The biosynthetic pathways differ between anaerobic and aerobic organisms, with the main pathway in anaerobic bacteria being clarified only recently, and there are various analytical techniques available for plasmalogen analysis.

PROGRESS IN LIPID RESEARCH (2021)

Editorial Material Biochemistry & Molecular Biology

Myxococcus xanthus

Michiel Vos

TRENDS IN MICROBIOLOGY (2021)

Review Biotechnology & Applied Microbiology

In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites

Chantal D. Bader et al.

BIOTECHNOLOGY ADVANCES (2020)

Article Multidisciplinary Sciences

The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens

Ernst R. Werner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase

Jiemin Shen et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

Review Microbiology

The Syntrophy hypothesis for the origin of eukaryotes revisited

Purificacion Lopez-Garcia et al.

NATURE MICROBIOLOGY (2020)

Review Biochemistry & Molecular Biology

S1P and plasmalogen derived fatty aldehydes in cellular signaling and functions

David L. Ebenezer et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)

Review Microbiology

Formation and function of bacterial organelles

Chris Greening et al.

NATURE REVIEWS MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

Yilong Zou et al.

NATURE (2020)

Review Cell Biology

Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine

Yulong Zhou et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Cell Biology

Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum

Masanori Honsho et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease

Sudip Paul et al.

PROGRESS IN LIPID RESEARCH (2019)

Review Biochemistry & Molecular Biology

On the road to unraveling the molecular functions of ether lipids

Noemi Jimenez-Rojo et al.

FEBS LETTERS (2019)

Article Biochemistry & Molecular Biology

B12-based photoreceptors: from structure and function to applications in optogenetics and synthetic biology

S. Padmanabhan et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)

Article Multidisciplinary Sciences

A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis

Aranzazu Gallego-Garcia et al.

SCIENCE (2019)

Review Cell Biology

Structural and functional roles of ether lipids

John M. Dean et al.

PROTEIN & CELL (2018)

Review Biochemistry & Molecular Biology

Plasmalogen lipids: functional mechanism and their involvement in gastrointestinal cancer

Marcia Cristina Fernandes Messias et al.

LIPIDS IN HEALTH AND DISEASE (2018)

Review Microbiology

Bacterial microcompartments

Cheryl A. Kerfeld et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Review Cell Biology

Understanding the diversity of membrane lipid composition

Takeshi Harayama et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Microbiology

Diversity of Myxobacteria-We Only See the Tip of the Iceberg

Kathrin I. Mohr

MICROORGANISMS (2018)

Review Chemistry, Multidisciplinary

Phosphonate Biochemistry

Geoff P. Horsman et al.

CHEMICAL REVIEWS (2017)

Review Biochemistry & Molecular Biology

The anaerobic biosynthesis of plasmalogens

Howard Goldfine

FEBS LETTERS (2017)

Article Chemistry, Multidisciplinary

AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus

Tobias Bock et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Review Microbiology

Myxobacteria: Moving, Killing, Feeding, and Surviving Together

Jose Munoz-Dorado et al.

FRONTIERS IN MICROBIOLOGY (2016)

Review Microbiology

Bacterial membrane lipids: diversity in structures and pathways

Christian Sohlenkamp et al.

FEMS MICROBIOLOGY REVIEWS (2016)

Article Multidisciplinary Sciences

X-ray structure of a mammalian stearoyl-CoA desaturase

Yonghong Bai et al.

NATURE (2015)

Article Multidisciplinary Sciences

Structural basis for gene regulation by a B12-dependent photoreceptor

Marco Jost et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate

Hui Wang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate

Hui Wang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

A multifunctional enzyme is involved in bacterial ether lipid biosynthesis

Wolfram Lorenzen et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Chemistry, Multidisciplinary

An Alternative Isovaleryl CoA Biosynthetic Pathway Involving a Previously Unknown 3-Methylglutaconyl CoA Decarboxylase

Yanyan Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Review Biochemistry & Molecular Biology

Orphan enzymes in ether lipid metabolism

Katrin Watschinger et al.

BIOCHIMIE (2013)

Article Biochemistry & Molecular Biology

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Jacqueline K. White et al.

Review Biochemistry & Molecular Biology

Functions of plasmalogen lipids in health and disease

Nancy E. Braverman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Review Microbiology

The early evolution of lipid membranes and the three domains of life

Jonathan Lombard et al.

NATURE REVIEWS MICROBIOLOGY (2012)

Review Microbiology

Light-dependent gene regulation in nonphototrophic bacteria

Montserrat Elias-Arnanz et al.

CURRENT OPINION IN MICROBIOLOGY (2011)

Article Multidisciplinary Sciences

Light-dependent gene regulation by a coenzyme B12-based photoreceptor

Juan Manuel Ortiz-Guerrero et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Oncology

Recruitment of Uev1B to Hrs-containing endosomes and its effect on endosomal trafficking

Jason E. Duex et al.

EXPERIMENTAL CELL RESEARCH (2010)

Article Multidisciplinary Sciences

Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes

Katrin Watschinger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

The appearance, disappearance and reappearance of plasmalogens in evolution

Howard Goldfine

PROGRESS IN LIPID RESEARCH (2010)

Review Biochemistry & Molecular Biology

Biosynthesis of Phosphonic and Phosphinic Acid Natural Products

William W. Metcalf et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Biosynthesis of 2-Hydroxy and iso-Even Fatty Acids is Connected to Sphingolipid Formation in Myxobacteria

Michael W. Ring et al.

CHEMBIOCHEM (2009)

Review Biochemistry & Molecular Biology

Desaturases: Emerging Models for Understanding Functional Diversification of Diiron-containing Enzymes

John Shanklin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Microbiology

Bacterial responses to photo-oxidative stress

Eva C. Ziegelhoffer et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Review Biochemistry & Molecular Biology

Odd-numbered very-long-chain fatty acids from the microbial, animal and plant kingdoms

Tomas Rezanka et al.

PROGRESS IN LIPID RESEARCH (2009)

Article Biochemistry & Molecular Biology

Independence and interdependence of Dif and Frz chemosensory pathways in Myxococcus xanthus chemotaxis

Qian Xu et al.

MOLECULAR MICROBIOLOGY (2008)

Article Microbiology

An anti-antisigma factor in the response of the bacterium Myxococcus xanthus to blue light

Lilian Galbis-Martinez et al.

MICROBIOLOGY-SGM (2008)

Review Microbiology

Chemosensory pathways, motility and development in Myxococcus xanthus

David R. Zusman et al.

NATURE REVIEWS MICROBIOLOGY (2007)

Article Microbiology

Novel lipids in Myxococcus xanthus and their role in chemotaxis

Patrick D. Curtis et al.

ENVIRONMENTAL MICROBIOLOGY (2006)

Review Biochemistry & Molecular Biology

Phospholipid directed motility of surface-motile bacteria

Pamela J. Bonner et al.

MOLECULAR MICROBIOLOGY (2006)

Article Biochemistry & Molecular Biology

A novel regulatory gene for light-induced carotenoid synthesis in the bacterium Myxococcus xanthus

M Fontes et al.

MOLECULAR MICROBIOLOGY (2003)