Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.849625
Keywords
ubiquitination; SUMOylation; cancer; metabolic reprogramming; glucose metabolism; lipid metabolism
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Funding
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2019jcyj-msxmX0429]
- National Natural Science Foundation of China [81672502]
- Venture & Innovation Support Program for Chongqing Overseas Returnees [cx2019131]
- National Undergraduate Training Programs for Innovation and Entrepreneurship of China [202010635062]
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Ubiquitination and SUMOylation play important roles in regulating cellular functions and signal transduction pathways, especially in cancer metabolic reprogramming. Understanding the regulatory mechanisms of these processes is crucial for understanding the molecular mechanisms of cancer development and developing new treatment methods.
Ubiquitination and SUMOylation, which are posttranslational modifications, play prominent roles in regulating both protein expression and function in cells, as well as various cellular signal transduction pathways. Metabolic reprogramming often occurs in various diseases, especially cancer, which has become a new entry point for understanding cancer mechanisms and developing treatment methods. Ubiquitination or SUMOylation of protein substrates determines the fate of modified proteins. Through accurate and timely degradation and stabilization of the substrate, ubiquitination and SUMOylation widely control various crucial pathways and different proteins involved in cancer metabolic reprogramming. An understanding of the regulatory mechanisms of ubiquitination and SUMOylation of cell proteins may help us elucidate the molecular mechanism underlying cancer development and provide an important theory for new treatments. In this review, we summarize the processes of ubiquitination and SUMOylation and discuss how ubiquitination and SUMOylation affect cancer metabolism by regulating the key enzymes in the metabolic pathway, including glucose, lipid and amino acid metabolism, to finally reshape cancer metabolism.
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