Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.886053
Keywords
ocular lens; transforming growth factor beta; epithelial to mesenchymal transition; fibrosis; cell adhesion
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
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Injury to the ocular lens disrupts cell-cell and cell-capsule/basement membrane interactions, leading to a series of interconnected signaling events. These events include cell-adhesion and growth factor-mediated signaling pathways that play a crucial role in the induction and progression of epithelial-mesenchymal transition (EMT) and fibrosis of lens epithelial cells. The lens provides a simple and ideal system to study injury-induced signaling pathways associated with EMT and fibrosis.
Injury to the ocular lens perturbs cell-cell and cell-capsule/basement membrane interactions leading to a myriad of interconnected signaling events. These events include cell-adhesion and growth factor-mediated signaling pathways that can ultimately result in the induction and progression of epithelial-mesenchymal transition (EMT) of lens epithelial cells and fibrosis. Since the lens is avascular, consisting of a single layer of epithelial cells on its anterior surface and encased in a matrix rich capsule, it is one of the most simple and desired systems to investigate injury-induced signaling pathways that contribute to EMT and fibrosis. In this review, we will discuss the role of key cell-adhesion and mechanotransduction related signaling pathways that regulate EMT and fibrosis in the lens.
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