Journal
JCI INSIGHT
Volume 7, Issue 9, Pages -Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.158277
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Funding
- NIH National Institute of Diabetes and Digestive and Kidney Diseases [R01DK125015, R01DK102843]
- Nephrotic Syndrome Study Network Career Development Award
- Children's Hospital of Pittsburgh Research Advisory Council Postdoctoral Fellowship
- University of Pittsburgh Summer Research Internship Program [R25DK119180]
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MicroRNAs play a significant role in kidney development and diseases, and can be used as biomarkers and therapeutic agents.
MicroRNAs (miRNAs) belong to a class of endogenous small noncoding RNAs that regulate gene expression at the posttranscriptional level, through both translational repression and mRNA destabilization. They are key regulators of kidney morphogenesis, modulating diverse biological processes in different renal cell lineages. Dysregulation of miRNA expression disrupts early kidney development and has been implicated in the pathogenesis of developmental kidney diseases. In this Review, we summarize current knowledge of miRNA biogenesis and function and discuss in detail the role of miRNAs in kidney morphogenesis and developmental kidney diseases, including congenital anomalies of the kidney and urinary tract and Wilms tumor. We conclude by discussing the utility of miRNAs as potentially novel biomarkers and therapeutic agents.
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