4.7 Article

Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress

Sandip M. Swain et al.

Summary: Both Piezo1 and TRPV4 ion channels are independently implicated in high venous pressure- and fluid shear stress-induced vascular hyperpermeability in endothelial cells. Piezo1 regulates TRPV4 channel activation in endothelial cells, with TRPV4 opening being dependent on the strength and duration of fluid shear stress. The deleterious effects initiated by Piezo1 in response to shear stress require the involvement of TRPV4 channels, as demonstrated by the calcium signaling and disruption of cellular integrity observed in endothelial cells.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Oncology

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

Yang Chen et al.

Summary: The stromal desmoplastic reaction in pancreatic ductal adenocarcinoma involves significant accumulation of type I collagen (Col1). Deletion of Col1 specifically in myofibroblasts accelerates PDAC progression by increasing Cxcl5 expression in cancer cells and promoting recruitment of myeloid-derived suppressor cells. Targeting CXCR2 and CCR2 may help restrain accelerated PDAC progression in the absence of stromal Col1.

CANCER CELL (2021)

Article Biochemistry & Molecular Biology

Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway

Meifang Zheng et al.

Summary: IL-6 promotes PSC activation and Col1 production through up-regulation of the TGF-beta 1/Smad2/3 pathway, potentially contributing to fibrogenesis in alcoholic chronic pancreatitis.

CYTOKINE (2021)

Article Multidisciplinary Sciences

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

Hamza Atcha et al.

Summary: Studies reveal that Piezo1 serves as a mechanosensor of stiffness in macrophages, influencing their polarization responses.

NATURE COMMUNICATIONS (2021)

Article Immunology

Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues

Hamza Atcha et al.

Summary: The study demonstrates that both cyclic and static stretch influence macrophage morphology and responses to different stimuli. The integrin CD11b and ion channel Piezo1 may play a role in mechanotransduction in macrophages.

FRONTIERS IN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses

Amit Jairaman et al.

Summary: In an animal model for multiple sclerosis, mice with genetic deletion of Piezo1 in T cells showed diminished disease severity. Piezo1 was not essential for lymph node homing, T cell proliferation, or differentiation into proinflammatory T helper cells, but its deletion resulted in enhanced TGF beta signaling and an expanded pool of regulatory T cells. Deletion of Piezo1 specifically in T-reg cells led to significant attenuation of EAE.

SCIENCE ADVANCES (2021)

Review Medicine, Research & Experimental

Role of macrophage TRPV4 in inflammation

Bidisha Dutta et al.

LABORATORY INVESTIGATION (2020)

Article Immunology

TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching

Rachel G. Scheraga et al.

JOURNAL OF IMMUNOLOGY (2020)

Article Medicine, Research & Experimental

TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation

Sandip M. Swain et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Immunology

TRPV4-A Missing Link Between Mechanosensation and Immunity

Laura Michalick et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Physiology

Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts

Francesca Aglialoro et al.

FRONTIERS IN PHYSIOLOGY (2020)

Review Multidisciplinary Sciences

Fibrosis: from mechanisms to medicines

Neil C. Henderson et al.

NATURE (2020)

Article Multidisciplinary Sciences

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Angel G. Solis et al.

NATURE (2019)

Review Genetics & Heredity

The role of TRPV4 in fibrosis

Lei Zhan et al.

Article Multidisciplinary Sciences

Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis

Joelle M. -J. Romac et al.

NATURE COMMUNICATIONS (2018)

Review Gastroenterology & Hepatology

Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment

Daniel Lew et al.

DIGESTIVE DISEASES AND SCIENCES (2017)

Article Gastroenterology & Hepatology

IL-6/STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells

Shin Hamada et al.

DIGESTIVE DISEASES AND SCIENCES (2016)

Article Medicine, Research & Experimental

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

ShengPeng Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Cell Biology

Piezo1 Channels Are Inherently Mechanosensitive

Ruhma Syeda et al.

CELL REPORTS (2016)

Article Multidisciplinary Sciences

Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain

Patrick Kanju et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Suitable parameter choice on quantitative morphology of A549 cell in epithelial-mesenchymal transition

Zhou-Xin Ren et al.

BIOSCIENCE REPORTS (2015)

Review Gastroenterology & Hepatology

Inflammation in acute and chronic pancreatitis

Aida Habtezion

CURRENT OPINION IN GASTROENTEROLOGY (2015)

Review Neurosciences

Mechanically Activated Ion Channels

Sanjeev S. Ranade et al.

NEURON (2015)

Article Multidisciplinary Sciences

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis

Jing Xue et al.

NATURE COMMUNICATIONS (2015)

Article Biology

Piezo1 links mechanical forces to red blood cell volume

Stuart M. Cahalan et al.

ELIFE (2015)

Article Pathology

Circulating Fibrocytes Stabilize Blood Vessels during Angiogenesis in a Paracrine Manner

Jinqing Li et al.

AMERICAN JOURNAL OF PATHOLOGY (2014)

Letter Gastroenterology & Hepatology

Chronic Pancreatitis and Pancreatic Cancer

Bai-Rong Li et al.

GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

Mortality, Cancer, and Comorbidities Associated With Chronic Pancreatitis: A Danish Nationwide Matched-Cohort Study

Ulrich Christian Bang et al.

GASTROENTEROLOGY (2014)

Article Medicine, Research & Experimental

TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

Shaik O. Rahaman et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Physiology

Prolonged high fat/alcohol exposure increases TRPV4 and its functional responses in pancreatic stellate cells

L. P. Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2013)

Review Gastroenterology & Hepatology

New insights into the pathogenesis of pancreatitis

Raghuwansh P. Sah et al.

CURRENT OPINION IN GASTROENTEROLOGY (2013)

Article Cardiac & Cardiovascular Systems

TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals

Ravi K. Adapala et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)

Article Multidisciplinary Sciences

Elementary Ca2+ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

Swapnil K. Sonkusare et al.

SCIENCE (2012)

Review Physiology

Pancreatic stellate cells: a starring role in normal and diseased pancreas

Minoti V. Apte et al.

FRONTIERS IN PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

Chilman Bae et al.

BIOCHEMISTRY (2011)

Article Cell Biology

Cross Talk among TGF-β Signaling Pathways, Integrins, and the Extracellular Matrix

John S. Munger et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Biochemistry & Molecular Biology

CCK1 and CCK2 Receptors Are Expressed on Pancreatic Stellate Cells and Induce Collagen Production

Marc J. Berna et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Gastroenterology & Hepatology

Macrophages: Master Regulators of Inflammation and Fibrosis

Thomas A. Wynn et al.

SEMINARS IN LIVER DISEASE (2010)

Review Medicine, Research & Experimental

The pancreatic stellate cell: a star on the rise in pancreatic diseases

M. Bishr Omary et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Gastroenterology & Hepatology

A new model of chronic pancreatitis in rats

Mitsuyoshi Yamamoto et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Article Multidisciplinary Sciences

Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4

J Vriens et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Abnormal osmotic regulation in trpv4-/- mice

W Liedtke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)