4.7 Article

Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race

Related references

Note: Only part of the references are listed.
Article Oncology

In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer

Sudhir B. Malla et al.

Summary: Positivity of DDIR does not predict improved response to oxaliplatin treatment in colorectal cancer, with DDIR-negative patients showing a trend towards better outcomes. The DDIR assay may have potential in identifying immune-rich tumors that could benefit from immune checkpoint blockade therapies, beyond the current use of MSI status.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

Race, Ethnicity, and Clinical Outcomes in Hormone Receptor-Positive, HER2-Negative, Node-Negative Breast Cancer in the Randomized TAILORx Trial

Kathy S. Albain et al.

Summary: The study revealed that black women with early breast cancer had worse clinical outcomes despite similar 21-gene recurrence score results and comparable systemic therapy. Hispanic ethnicity and Asian race were associated with better outcomes.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Oncology

Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons

Muhlis Akman et al.

Summary: Solid tumors often grow in low oxygen tension microenvironments, which along with aberrant activation of specific oncogenic pathways, increase the activity of HIF-1 alpha and induce ER stress, ultimately leading to chemoresistance. Interventions targeting HIF-1 alpha and ER stress may serve as potential strategies to sensitize hypoxic and chemorefractory tumors in the future.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Oncology

Breast Tumor Microenvironment in Black Women: A Distinct Signature of CD8+ T-Cell Exhaustion

Song Yao et al.

Summary: This study found marked differences in tumor immune responses between Black and White breast cancer patients, with Blacks showing a stronger immune presence and distinct immune cell composition and quality. A signature indicating a higher ratio of exhausted CD8(+) T cells was consistently associated with poorer survival, particularly in hormone receptor-positive patients, suggesting a basis for their more aggressive disease and a rationale for the use of immune checkpoint inhibitors.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Biology

Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival

Sandeep K. Singhal et al.

Summary: The study applies digital pathology to analyze the subcellular distribution of the transcription factor Kaiso in breast cancer tumors, revealing novel associations with other biomarkers and providing insights into Kaiso's role in breast cancer progression. Automated image analysis quantifies the distribution of Kaiso, showing correlations with breast cancer subtype, overall survival, and a link with the autophagy marker LC3.

COMMUNICATIONS BIOLOGY (2021)

Article Oncology

Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry

Zhaohui Du et al.

Summary: The study found that polygenic risk scores can stratify breast cancer risk in women of African ancestry, but with attenuated performance compared to European, Asian, and Latino populations. Further work is needed to improve breast cancer risk stratification for women of African ancestry.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Article Oncology

Targeting the CtBP1-FOXM1 transcriptional complex with small molecules to overcome MDR1-mediated chemoresistance in osteosarcoma cancer stem cells

Xun Chen et al.

Summary: The study identified that the CtBP1-FOXM1 complex activates MDR1 expression in cisplatin-resistant osteosarcoma cancer stem cells, leading to chemoresistance. Targeting this complex with specific inhibitors can reverse MDR1-mediated chemoresistance, offering a new therapeutic strategy for overcoming chemoresistance during osteosarcoma treatment.

JOURNAL OF CANCER (2021)

Review Oncology

Endoplasmic reticulum stress signals in the tumour and its microenvironment

Xi Chen et al.

Summary: This review explores how ER stress in the tumor microenvironment can influence the functions of cancer cells and immune cells, leading to vulnerabilities that could be targeted by emerging therapeutic strategies. The tightly regulated processes of protein handling, modification, and folding in the ER determine cell function and survival, and disruptions in ER homeostasis can result in a state of persistent ER stress with pro-tumoral effects in cancer cells and immunomodulatory effects in immune cells.

NATURE REVIEWS CANCER (2021)

Review Cell Biology

When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

Matias Gonzalez-Quiroz et al.

TRENDS IN CELL BIOLOGY (2020)

Letter Oncology

Re: Black-White Breast Cancer Incidence Trends: Effects of Ethnicity

Carol E. DeSantis et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Article Biochemistry & Molecular Biology

The ubiquitin specific protease USP34 protects the ubiquitin ligase gp78 from proteasomal degradation

Hui Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Medicine, Research & Experimental

ERR1-and PGC1α-associated mitochondrial alterations correlate with pan-cancer disparity in African Americans

Danthasinghe Waduge Badrajee Piyarathna et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Physiology

Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases

Mafalda Escobar-Henriques et al.

FRONTIERS IN PHYSIOLOGY (2019)

Article Biochemistry & Molecular Biology

Atlas of Subcellular RNA Localization Revealed by APEX-Seq

Furqan M. Fazal et al.

Article Oncology

Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study

Melissa A. Troester et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Article Oncology

Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study

Melissa A. Troester et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Article Oncology

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

Eileen E. Parkes et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Oncology

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

Eileen E. Parkes et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Review Neurosciences

Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis

Vibhuti Joshi et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

Article Oncology

Breast cancer statistics, 2017, racial disparity in mortality by state

Carol E. DeSantis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

Article Oncology

Breast Cancer Statistics, 2015: Convergence of Incidence Rates Between Black and White Women

Carol E. DeSantis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

Article Oncology

Cancer statistics for African Americans, 2016: Progress and opportunities in reducing racial disparities

Carol E. DeSantis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

Article Oncology

Chromosomal instability as a prognostic marker in cervical cancer

Christine How et al.

BMC CANCER (2015)

Review Oncology

ER proteostasis addiction in cancer biology: Novel concepts

Estefanie Dufey et al.

SEMINARS IN CANCER BIOLOGY (2015)

Article Oncology

US Incidence of Breast Cancer Subtypes Defined by Joint Hormone Receptor and HER2 Status

Nadia Howlader et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)

Article Cell Biology

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase

Min Fu et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

Article Biochemistry & Molecular Biology

The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks

Shirley M. H. Sy et al.

NUCLEIC ACIDS RESEARCH (2013)

Review Biochemistry & Molecular Biology

gp78: a Multifaceted Ubiquitin Ligase that Integrates a Unique Protein Degradation Pathway from the Endoplasmic Reticulum

Zhiliang Chen et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2012)

Article Oncology

Gene Modules and Response to Neoadjuvant Chemotherapy in Breast Cancer Subtypes: A Pooled Analysis

Michail Ignatiadis et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)

Article Oncology

Age-Specific Incidence of Breast Cancer Subtypes: Understanding the BlackWhite Crossover

Christina A. Clarke et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2012)

Article Biochemical Research Methods

Multisite Phosphorylation of Human Liver Cytochrome P450 3A4 Enhances Its gp78- and CHIP-mediated Ubiquitination

YongQiang Wang et al.

MOLECULAR & CELLULAR PROTEOMICS (2012)

Article Multidisciplinary Sciences

ELL facilitates RNA polymerase II pause site entry and release

Jung S. Byun et al.

NATURE COMMUNICATIONS (2012)

Article Medicine, General & Internal

A Genomic Predictor of Response and Survival Following Taxane-Anthracycline Chemotherapy for Invasive Breast Cancer

Christos Hatzis et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Article Biochemistry & Molecular Biology

The Endoplasmic Reticulum (ER)-associated Degradation System Regulates Aggregation and Degradation of Mutant Neuroserpin

Zheng Ying et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Oncology

Multifactorial Approach to Predicting Resistance to Anthracyclines

Christine Desmedt et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

Article Biochemistry & Molecular Biology

A Role for KAI1 in Promotion of Cell Proliferation and Mammary Gland Hyperplasia by the gp78 Ubiquitin Ligase

Bharat Joshi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases

Michael K. Pabarcus et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)

Review Pathology

MammaPrint™ 70-gene signature: another milestone in personalized medical care for breast cancer patients

Elzbieta A. Slodkowska et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2009)

Article Biochemistry & Molecular Biology

Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation

Zheng Ying et al.

HUMAN MOLECULAR GENETICS (2009)

Article Oncology

Genomic Grade Index Is Associated With Response to Chemotherapy in Patients With Breast Cancer

Cornelia Liedtke et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

Review Oncology

Autocrine motility factor receptor: a clinical review

Connie G. Chiu et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2008)

Article Biochemistry & Molecular Biology

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

Yien Che Tsai et al.

NATURE MEDICINE (2007)

Article Biochemistry & Molecular Biology

ER stress differentially regulates the stabilities of ERAD ubiquitin ligases and their substrates

Yuxian Shen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Biochemistry & Molecular Biology

Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78

Joon No Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of α-1-antitrypsin

Yuxian Shen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Biochemical Research Methods

Pvclust: an R package for assessing the uncertainty in hierarchical clustering

R Suzuki et al.

BIOINFORMATICS (2006)

Article Multidisciplinary Sciences

The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain,, RING finger, and an E2-binding site

B Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biochemical Research Methods

The application of tissue microarrays in the validation of microarray results

Stephen M. Hewitt

DNA MICROARRAYS PART A: ARRAY PLATFORMS AND WET-BENCH PROTOCOLS (2006)

Article Oncology

B7-H4 is highly expressed in ductal and lobular breast cancer

B Tringler et al.

CLINICAL CANCER RESEARCH (2005)

Article Biochemistry & Molecular Biology

The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum

M Registre et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Multidisciplinary Sciences

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

SY Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)