Related references
Note: Only part of the references are listed.Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
Katja Peschke et al.
EMBO MOLECULAR MEDICINE (2022)
MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma
Ravikanth Maddipati et al.
CANCER DISCOVERY (2022)
The SUMO pathway in pancreatic cancer: insights and inhibition
Christian Schneeweis et al.
BRITISH JOURNAL OF CANCER (2021)
Cancer Statistics, 2021
Rebecca L. Siegel et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2021)
A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma
R. Nicolle et al.
ANNALS OF ONCOLOGY (2021)
Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
Dirk Brehmer et al.
MOLECULAR CANCER THERAPEUTICS (2021)
PRMT5 inhibition disrupts splicing and stemness in glioblastoma
Patty Sachamitr et al.
NATURE COMMUNICATIONS (2021)
PRMT1 promotes the tumor suppressor function of p14ARF and is indicative for pancreatic cancer prognosis
Antje Repenning et al.
EMBO JOURNAL (2021)
Rationale for MYC imaging and targeting in pancreatic cancer
Gunter Schneider et al.
EJNMMI RESEARCH (2021)
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma
Yuhong Luo et al.
HEPATOLOGY (2021)
Pancreas cancer: Therapeutic trials in metastatic disease
James W. Smithy et al.
JOURNAL OF SURGICAL ONCOLOGY (2021)
Estimated Projection of US Cancer Incidence and Death to 2040
Lola Rahib et al.
JAMA NETWORK OPEN (2021)
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
Virginia Giuliani et al.
NATURE COMMUNICATIONS (2021)
Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects
Joshua M. Dempster et al.
GENOME BIOLOGY (2021)
SUMO pathway inhibition targets an aggressive pancreatic cancer subtype
Alexander Biederstadt et al.
GUT (2020)
PRMT5 promotes epithelial-mesenchymal transition via EGFR-β-catenin axis in pancreatic cancer cells
Lu Ge et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)
Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution
Michelle Chan-Seng-Yue et al.
NATURE GENETICS (2020)
HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
Holly Brunton et al.
CELL REPORTS (2020)
SynergyFinder 2.0: visual analytics of multi-drug combination synergies
Aleksandr Ianevski et al.
NUCLEIC ACIDS RESEARCH (2020)
Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology
Zahra Dantes et al.
JCI INSIGHT (2020)
Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC
Katharina Lankes et al.
MOLECULAR ONCOLOGY (2020)
Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells
Xiaolong Wei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis
Yi Qin et al.
CELL COMMUNICATION AND SIGNALING (2019)
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase
Steffi Herold et al.
NATURE (2019)
PRMT1 loss sensitizes cells to PRMT5 inhibition
Guozhen Gao et al.
NUCLEIC ACIDS RESEARCH (2019)
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens
Fiona M. Behan et al.
NATURE (2019)
The regulation, functions and clinical relevance of arginine methylation
Ernesto Guccione et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
PRMTs and Arginine Methylation: Cancer's Best-Kept Secret?
James Jarrold et al.
TRENDS IN MOLECULAR MEDICINE (2019)
Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer
Assaf Magen et al.
CELL REPORTS (2019)
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation
Jia Yi Fong et al.
CANCER CELL (2019)
Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine
Gwen Lomberk et al.
NATURE COMMUNICATIONS (2019)
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
Damian Szklarczyk et al.
NUCLEIC ACIDS RESEARCH (2019)
Pancreatic cancer organoids recapitulate disease and allow personalized drug screening
Else Driehuis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility
Erik S. Knudsen et al.
GUT (2018)
Curation of the Pancreatic Ductal Adenocarcinoma Subset of the Cancer Genome Atlas Is Essential for Accurate Conclusions about Survival-Related Molecular Mechanisms
Ivana Peran et al.
CLINICAL CANCER RESEARCH (2018)
CLK2 blockade modulates alternative splicing compromising MYC-driven breast tumors
Fernando Salvador et al.
EMBO MOLECULAR MEDICINE (2018)
An enhanced CRISPR repressor for targeted mammalian gene regulation
Nan Cher Yeo et al.
NATURE METHODS (2018)
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Herve Tiriac et al.
CANCER DISCOVERY (2018)
Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing
Sarah Gerhart et al.
SCIENTIFIC REPORTS (2018)
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes
Sebastian Mueller et al.
NATURE (2018)
Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer
Luz Garcia-Alonso et al.
CANCER RESEARCH (2018)
MYC-Master Regulator of the Cancer Epigenome and Transcriptome
Candace J. Poole et al.
GENES (2017)
Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma
Christian J. Braun et al.
CANCER CELL (2017)
The MYC mRNA 3′-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels
Francesca R. Dejure et al.
EMBO JOURNAL (2017)
Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts
Benjamin Bian et al.
EMBO MOLECULAR MEDICINE (2017)
Tissue-specific tumorigenesis: context matters
Guenter Schneider et al.
NATURE REVIEWS CANCER (2017)
Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666
Kenneth W. Duncan et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Multi-omics enrichment analysis using the GeneTrail2 web service
Daniel Stoeckel et al.
BIOINFORMATICS (2016)
Concepts to Target MYC in Pancreatic Cancer
Matthias Wirth et al.
MOLECULAR CANCER THERAPEUTICS (2016)
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey et al.
NATURE (2016)
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
Kanak Raina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Konstantinos J. Mavrakis et al.
SCIENCE (2016)
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Gregory V. Kryukov et al.
SCIENCE (2016)
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
Katya Marjon et al.
CELL REPORTS (2016)
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Silvana Konermann et al.
NATURE (2015)
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
Tiffany Y. -T. Hsu et al.
NATURE (2015)
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
Cheryl M. Koh et al.
NATURE (2015)
Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
Agnieszka K. Witkiewicz et al.
NATURE COMMUNICATIONS (2015)
Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model
Bhagwan Yadav et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2015)
Deregulated MYC expression induces dependence upon AMPK-related kinase 5
Lidan Liu et al.
NATURE (2012)
Functional genomics identifies therapeutic targets for MYC-driven cancer
Masafumi Toyoshima et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis
Jessica D. Kessler et al.
SCIENCE (2012)
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase
Dun Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Share Paper
