☆ 4.7 Article

Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients

JCI INSIGHT (2022)

Related references

Note: Only part of the references are listed.

Article Surgery

Insufficient response to mRNA SARS-CoV-2 vaccine and high incidence of severe COVID-19 in kidney transplant recipients during pandemic

Tomas Reischig et al.

Summary: This study found that the protection of SARS-CoV-2 mRNA vaccination against COVID-19 is limited in kidney transplant recipients, with some patients developing COVID-19 after vaccination having lower levels of anti-spike protein IgG. While some patients were able to produce higher IgG levels after COVID-19, overall humoral responses were not significant, leading to suboptimal efficacy post-vaccination.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

Add to Collection

Article Surgery

Intensity of mycophenolate mofetil treatment is associated with an impaired immune response to SARS-CoV-2 vaccination in kidney transplant recipients

Marta Kantauskaite et al.

Summary: Kidney transplant recipients (KTRs) have a weaker immune response to SARS-CoV-2 vaccination compared to controls, with mycophenolate mofetil (MMF) treatment being the strongest predictor for impaired response. Adjusting MMF dose may improve the immune response in KTRs.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

Add to Collection

Letter Rheumatology

Temporary hold of mycophenolate augments humoral response to SARS-CoV-2 vaccination in patients with rheumatic and musculoskeletal diseases: a case series

Caoilfhionn M. Connolly et al.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Add to Collection

Article Surgery

Mucosal associated invariant T cells are differentially impaired in tolerant and immunosuppressed liver transplant recipients

Arne Sattler et al.

Summary: Immunosuppressants can affect the activation and functional competence of MAIT cells, particularly in liver transplant recipients, leading to impaired activation and function both in vitro and in vivo.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Add to Collection

Article Immunology

Inosine 5′-Monophosphate Dehydrogenase Activity for the Longitudinal Monitoring of Mycophenolic Acid Treatment in Kidney Allograft Recipients

Petra Glander et al.

Summary: IMPDH activity in erythrocytes can be used to monitor the effects of MPA treatment on organ transplantation, reflecting drug exposure. Dosage, body mass index, renal function, and coimmunosuppression influence IMPDH activity. Patients with lower IMPDH activity are more likely to experience acute rejection. IMPDH has predictive value in predicting rejection and MPA-associated adverse events.

TRANSPLANTATION (2021)

Add to Collection

Article Immunology

Independent Side-by-Side Validation and Comparison of 4 Serological Platforms for SARS-CoV-2 Antibody Testing

Bernd Jahrsdoerfer et al.

Summary: This study provides a comparative validation of 4 anti-SARS-CoV-2 platforms, with Euroimmun and Roche platforms showing the highest sensitivities for screening individuals at increased risk of SARS-CoV-2 infections.

JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Article Urology & Nephrology

B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients

Eva Schrezenmeier et al.

Summary: The study found that 36% of kidney transplant recipients showed seroconversion after receiving a third dose of vaccine, highlighting the need for individual humoral monitoring and continued efforts to adapt vaccination protocols for immunosuppressed individuals. The quantitative and qualitative changes in cellular immunity associated with seroconversion emphasize the importance of modified vaccination approaches for this at-risk group.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Add to Collection

Article Public, Environmental & Occupational Health

The Advisory Committee on Immunization Practices’ Interim Recommendations for Additional Primary and Booster Doses of COVID-19 Vaccines — United States, 2021

Sarah Mbaeyi et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

Add to Collection

Letter Medicine, General & Internal

Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients

Brian J. Boyarsky et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Article Immunology

Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19-Convalescent Donors

Bernd Jahrsdoerfer et al.

Summary: The study revealed that SARS-CoV-2 neutralization titers remain stable or even increase for at least seven months after diagnosis, showing a positive correlation with age, symptom number, and specific antigen presence. Platform validation indicated the wild-type virus and surrogate neutralization tests had the highest assay performances, but the selection of cutoff titers significantly affected the evaluation of neutralization potency.

JOURNAL OF IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study-The COViNEPH Project

Alicja Debska-Slizien et al.

Summary: The humoral response to SARS-CoV-2 vaccination among kidney transplant recipients is low, with older age, shorter transplantation time, and use of more than two immunosuppressive drugs being independent predictors of a low response.

VACCINES (2021)

Add to Collection

Letter Medicine, General & Internal

Assessment of 4 Doses of SARS-CoV-2 Messenger RNA-Based Vaccine in Recipients of a Solid Organ Transplant

Nassim Kamar et al.

JAMA NETWORK OPEN (2021)

Add to Collection

Review Health Care Sciences & Services

Planned Pregnancy in Kidney Transplantation. A Calculated Risk

Claudio Ponticelli et al.

Summary: Pregnancy in kidney transplant women carries risks of maternal and fetal complications. Preconception counseling, maternal medical management, and proper drug use are crucial factors influencing the outcome of pregnancy in this population. Careful monitoring and medication adjustments are necessary to minimize potential fetotoxicity and adverse outcomes.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Add to Collection

Article Transplantation

Absolute or Relative Quantification of Donor-derived Cell-free DNA in Kidney Transplant Recipients: Case Series

Bilgin Osmanodja et al.

Summary: The debate on whether relative or absolute quantification of dd-cfDNA is more reliable for the detection of acute transplant injury continues. This study found discrepancies in relative and absolute quantification of dd-cfDNA in late posttransplant patients, with reasons including infections, low leukocyte count, and variability in total cfDNA levels. Relying solely on relative dd-cfDNA may lead to false-negative and false-positive results, suggesting the use of both absolute and relative quantification for higher reliability in clinical settings, particularly in patients with chronic active antibody-mediated rejection.

TRANSPLANTATION DIRECT (2021)

Add to Collection

Article Multidisciplinary Sciences

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Danilo Schmidt et al.

Summary: TBase is an electronic health record tailored for kidney transplant recipients, offering automated and manual data entry to create a comprehensive database. It facilitates routine clinical care and research with high data quality, and also enables the implementation of Machine Learning algorithms for clinical care.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2021)

Add to Collection

Article Surgery

Weak antibody response to three doses of mRNA vaccine in kidney transplant recipients treated with belatacept

Nathalie Chavarot et al.

Summary: Poor responses to mRNA COVID-19 vaccine were observed in kidney transplant recipients treated with belatacept, especially in those without prior COVID-19 history. However, patients with a history of COVID-19 developed a strong antibody response with high titers after vaccination. Further strategies are needed to improve protection in this population.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Add to Collection

Article Multidisciplinary Sciences

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

Ugur Sahin et al.

Summary: The BNT162b2 vaccine shows 95% efficacy in preventing COVID-19 by boosting neutralizing antibody titres and activating specific T cell responses. The vaccine-induced immune response is broad and stable, lasting for a prolonged period, providing good coverage against various SARS-CoV-2 variants.

NATURE (2021)

Add to Collection

Review Urology & Nephrology

Liquid biopsies: donor-derived cell-free DNA for the detection of kidney allograft injury

Michael Oellerich et al.

Summary: Donor-derived cell-free DNA (dd-cfDNA) serves as a potential biomarker in kidney transplantation for early detection and monitoring of rejection, guiding immunosuppressive therapy, and reducing the risk of unnecessary biopsies.

NATURE REVIEWS NEPHROLOGY (2021)

Add to Collection

Letter Medicine, General & Internal

Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients

Nassim Kamar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Multidisciplinary Sciences

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

Lucie Loyal et al.

Summary: The study demonstrates that preexisting spike-cross-reactive T cells play a functional role in the immune response to SARS-CoV-2 infection and vaccination. Cross-reactive immunity may explain the rapid induction of immunity after primary SARS-CoV-2 immunization and the high rate of asymptomatic or mild COVID-19 cases.

SCIENCE (2021)

Add to Collection

Editorial Material Immunology

Antibody Response to a Fourth Dose of a SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: A Case Series

Jennifer L. Alejo et al.

TRANSPLANTATION (2021)

Add to Collection

Letter Immunology

Two Doses of SARS-CoV-2 Vaccines Reduce Risk of Death Due to COVID-19 in Solid Organ Transplant Recipients: Preliminary Outcomes From a UK Registry Linkage Analysis

Rommel Ravanan et al.

TRANSPLANTATION (2021)

Add to Collection

Article Immunology

Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients

Hector Rincon-Arevalo et al.

Summary: Patients with kidney failure are at increased risk for SARS-CoV-2 infection, making effective vaccination critical. However, studies have found significantly impaired antibody responses to the BNT162b2 vaccine in kidney transplant recipients and dialysis patients, leading to insufficient immune responses.

SCIENCE IMMUNOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients

Arne Sattler et al.

Summary: The study analyzed immune responses in kidney transplant recipients after receiving the BNT162b2 vaccine, finding weaker antibody responses in transplant patients compared to healthy individuals and most hemodialysis patients. Additionally, spike-specific T cell responses were significantly reduced in transplant patients, indicating a need for revised vaccination strategies in immunosuppressed individuals.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Medical Laboratory Technology

Time-Dependent Apparent Increase in dd-cfDNA Percentage in Clinically Stable Patients Between One and Five Years Following Kidney Transplantation

Ekkehard Schutz et al.

CLINICAL CHEMISTRY (2020)

Add to Collection

Article Medicine, Research & Experimental

SARS-CoV-2-specific T cell responses and correlations with COVID-19 patient predisposition

Arne Sattler et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Add to Collection

Article Surgery

Absolute quantification of donor-derived cell-free DNA as a marker of rejection and graft injury in kidney transplantation: Results from a prospective observational study

Michael Oellerich et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2019)

Add to Collection

Article Medicine, Research & Experimental

Mycophenolate mofetil reduces STAT3 phosphorylation in systemic lupus erythematosus patients

Samantha Slight-Webb et al.

JCI INSIGHT (2019)

Add to Collection

Article Surgery

Donor-Recipient Matching Based on Predicted Indirectly Recognizable HLA Epitopes Independently Predicts the Incidence of De Novo Donor-Specific HLA Antibodies Following Renal Transplantation

N. Lachmann et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2017)

Add to Collection

Article Urology & Nephrology

A revised strategy for monitoring BKV-specific cellular immunity in kidney transplant patients

Benjamin J. D. Weist et al.

KIDNEY INTERNATIONAL (2015)

Add to Collection

Article Medical Laboratory Technology

Digital Droplet PCR for Rapid Quantification of Donor DNA in the Circulation of Transplant Recipients as a Potential Universal Biomarker of Graft Injury

Julia Beck et al.

CLINICAL CHEMISTRY (2013)

Add to Collection

Article Surgery

Long-term outcomes after cyclosporine or mycophenolate withdrawal in kidney transplantation results from an aborted trial

Anders Asberg et al.

CLINICAL TRANSPLANTATION (2013)

Add to Collection

Article Immunology

Combined standard and novel immunosuppressive substances affect B-lymphocyte function

Mareen Matz et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2013)

Add to Collection

Article Surgery

Effects of sotrastaurin, mycophenolic acid and everolimus on human B-lymphocyte function and activation

Mareen Matz et al.

TRANSPLANT INTERNATIONAL (2012)

Add to Collection

Article Immunology

Randomized Trial Comparing Late Concentration-Controlled Calcineurin Inhibitor or Mycophenolate Mofetil Withdrawal

Jacqueline S. Mourer et al.

TRANSPLANTATION (2012)

Add to Collection

Article Rheumatology

Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus

Sebastian Eickenberg et al.

ARTHRITIS RESEARCH & THERAPY (2012)

Add to Collection

Article Surgery

Mycophenolic Acid-Mediated Suppression of Human CD4+ T Cells: More Than Mere Guanine Nucleotide Deprivation

X. He et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2011)

Add to Collection

Article Immunology

Mycophenolic Acid Differentially Impacts B Cell Function Depending on the Stage of Differentiation

Jodi L. Karnell et al.

JOURNAL OF IMMUNOLOGY (2011)

Add to Collection

Article Immunology

Three-year observational follow-up of a multicenter, Randomized trial on tacrolimus-based therapy with withdrawal of steroids or mycophenolate mofetil after renal transplant

Julio Pascual et al.

TRANSPLANTATION (2006)

Add to Collection

Article Surgery

Minimization of immunosuppressive therapy after renal transplantation: Results of a randomized controlled trial

Y Vanrenterghem et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2005)

Add to Collection

Article Immunology

Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals

G Cassese et al.

JOURNAL OF IMMUNOLOGY (2003)

Add to Collection

Article Hematology

Interleukin-6 is a growth factor for nonmalignant human plasmablasts

G Jego et al.

BLOOD (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.