4.6 Article

Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds

Journal

RESEARCH
Volume 2022, Issue -, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.34133/2022/9762746

Keywords

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Funding

  1. National Natural Science Foundation of China [52103096]
  2. Natural Science Foundation of Chongqing, China [cstc2020jcyjmsxmX0383]
  3. Fundamental Research Funds for the Central Universities [SWU-KT22004]
  4. Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars [cx2019050]
  5. Innovation Project for Graduate Student of Chongqing [CYB21121]

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This study developed a Janus particle, SEC-Fe@CaT, that achieved rapid hemostasis in complex and deep wounds. The particle utilized bubble-driving and magnetic field-mediated forces to diffuse in the blood and access deep bleeding sites. Animal tests showed that SEC-Fe@CaT significantly reduced bleeding time compared to a commercial product.
Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty in delivering hemostats to these sites. In this study, a Janus particle, SEC-Fe@CaT with dual-driven forces, bubble-driving, and magnetic field- (MF-) mediated driving, was prepared via in situ loading of Fe3O4 on a sunflower sporopollenin exine capsule (SEC), and followed by growth of flower-shaped CaCO3 clusters. The bubble-driving forces enabled SEC-Fe@CaT to self-diffuse in the blood to eliminate agglomeration, and the MF-mediated driving force facilitated the SEC-Fe@CaT countercurrent against blood to access deep bleeding sites in the wounds. During the movement in blood flow, the meteor hammer-like SEC from SEC-Fe@CaT can puncture red blood cells (RBCs) to release procoagulants, thus promoting activation of platelet and rapid hemostasis. Animal tests suggested that SEC-Fe@CaT stopped bleeding in as short as 30 and 45 s in femoral artery and liver hemorrhage models, respectively. In contrast, the similar commercial product Celoxr (TM) required approximately 70 s to stop the bleeding in both bleeding modes. This study demonstrates a new hemostat platform for rapid hemostasis in deep and complex wounds. It was the first attempt integrating geometric structure of sunflower pollen with dual-driven movement in hemostasis.

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