Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 143, Issue 7, Pages 1107-1122Publisher
SPRINGER
DOI: 10.1007/s00432-016-2325-y
Keywords
Breast cancer; Vitamin D; Vitamin D receptor; Estrogen receptor; HER2
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Funding
- China Scholarship Council (CSC) [201508080093]
- University Paul Sabatier in Toulouse (France)
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Breast cancer is a significant global public health issue. It is the leading cause of death among women around the world, with an incidence increasing annually. In recent years, there has been more and more information in the literature regarding a protective role of vitamin D in cancer. Increasingly preclinical and clinical studies suggest that vitamin D optimal levels can reduce the risk of breast cancer development and regulate cancer-related pathways. In this review, we focus on the importance of vitamin D in breast cancers, discussing especially the influence of vitamin D signaling on estrogen receptor and human epidermal growth factor receptor 2 (HER2), two major biomarkers of breast cancer today. We discuss the possibility of actual and future targeted therapeutic approaches for vitamin D signaling in breast cancer.
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