Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 142, Issue 11, Pages 2231-2237Publisher
SPRINGER
DOI: 10.1007/s00432-016-2183-7
Keywords
Long noncoding RNA; Biological function; Regulatory mechanism; Gene expression; Tumorigenesis; Clinical relevance
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Funding
- Zhejiang Provincial Natural Science Foundation of China [LY14C060003]
- Applied Research Project on Nonprofit Technology of Zhejiang Province [2016C33177]
- National Natural Science Foundation of China [81171660]
- K. C. Wong Magna Fund in Ningbo University
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Gastric cancer ranks as the most common cancer in the world. However, the progresses of its diagnosis and treatment are still not satisfactory. The purpose of this study is to summarize the roles of lncRNAs associated with gastric cancer. We searched lncRNAs associated with gastric cancer in PubMed. Long noncoding RNAs (lncRNAs), transcripts larger than 200 nucleotides, regulate gene expression at various levels. They are playing important roles in the occurrence and development of gastric cancer. They are involved in signaling pathways, crosstalk with microRNAs, and affecting metastasis by regulating epithelial-to-mesenchymal transition. By acting as oncogenes or tumor suppressors, lncRNAs contribute to gastric cancer occurrence and development. Several lncRNAs including HOTAIR, HULC, LINC00152, MALAT2, H19, GHET1, and GACAT3 have been demonstrated having oncogene activities, while other lncRNAs including LEIGC, GAS5, and FER1L4 have been thought as tumor suppressors. Several lncRNAs from tissue, blood, and gastric juice have shown potential values in gastric cancer diagnosis or prognosis evaluation.
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