4.4 Review

Patterns of liver profile disturbance in patients with COVID-19

Journal

WORLD JOURNAL OF CLINICAL CASES
Volume 10, Issue 7, Pages 2063-2071

Publisher

BAISHIDENG PUBLISHING GROUP INC
DOI: 10.12998/wjcc.v10.i7.2063

Keywords

Liver functions; COVID-19; Liver profile; Alanine transaminase; aspartate transaminase; Bilirubin

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COVID-19 can cause liver disturbance, leading to liver disease. The molecular mechanism is still unknown, but it may be related to pre-existing liver diseases.
Fever and cough are the most common clinical symptoms of coronavirus disease 2019 (COVID-19), but complications (such as pneumonia, respiratory distress syndrome, and multiorgan failure) can occur in people with additional comorbidities. COVID-19 may be a new cause of liver disease, as liver profile disturbance is one of the most common findings among patients. The molecular mechanism underlying this phenomenon, however, is still unknown. In this paper, we review the most current research on the patterns of change in liver profile among patients with COVID-19, the possible explanation for these findings, and the relation to pre-existing liver disease in these patients.

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