FINCA syndrome-Defining neurobehavioral phenotype in survivors into late childhood

Background: By 2021, 10 cases of fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA, MIM #618278) syndrome have been reported, and five causative variants in the NHLRC2 gene (*618277) have been identified. First reported patients presented with recurrent respiratory distress, leading to death before the age of 3. In the recent publication by Rapp, Van Dijck, and Laugwitz et al., six more patients were described. The authors underlined the possibility of survival beyond infancy and neurodevelopmental delay occurrence. Methods: Our goal is to characterize further neurobehavioral phenotype of patients with the NHLRC2 gene variants. Therefore, we describe three previously unreported patients with FINCA's clinical features who survived into late childhood and reviewed the neurobehavioral phenotype of all known cases. Results: We identify the so far unfamiliar neurological features of FINCA syndrome and a novel variant in the NHLRC2: c.977G>T, p.(G326V) detected in one of the patients.

Automated summary

The study aims to characterize the neurobehavioral phenotype of patients with NHLRC2 gene variants. Three previously unreported patients with FINCA syndrome were described, and the neurobehavioral phenotype of all known cases was reviewed. The study identified unfamiliar neurological features of FINCA syndrome and a novel variant in the NHLRC2 gene.