Journal
ADIPOCYTE
Volume 11, Issue 1, Pages 153-163Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21623945.2022.2042963
Keywords
Adipose tissue composition; migration; water-fat imaging; cardiometabolic disease; MRI
Categories
Funding
- Lund University (ALF grants) [20101641, 20101837, 162641]
- Swedish Research Council
- LUDC [349-2006-237]
- Exodiab [2009-1039, 2019-00978]
- Swedish foundation for Strategic Research [LUDC IRC15-0067]
- Novo Nordisk [NNF20OC0063659]
- General Hospital of Malmo Foundation for Fighting Cancer
- Cancer Research Foundation at the Department of Oncology, Malmo University Hospital
- Allmanna Sjukhusets i Malmo Stiftelse for Bekampande av Cancer
- Lunds Universitet [20101837, 162641, ALF 20101641]
- Cancer Research Foundation, Department of Oncology, Malmo University Hospital
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Middle Eastern immigrants, especially those of Iraqi descent, have a more favorable fatty acid composition in their abdominal adipose tissue compared to Swedish-born individuals. Additionally, differences in fatty acid composition were observed between different abdominal compartments, suggesting a potential protective effect against insulin resistance.
Middle Eastern immigrants are at high-risk for insulin resistance. Fatty acid composition (FAC) plays an important role in the development of insulin resistance but has not been investigated in people of Middle Eastern ancestry. Here, the aim was to assess the FAC in visceral and subcutaneous adipose tissue (VAT and SAT) in healthy Iraqi- and Swedish-born men using a magnetic resonance imaging (MRI) method.This case-control study included 23 Iraqi- and 15 Swedish-born middle-aged men, without cardiometabolic disease. Using multi-echo MRI of the abdomen, the fractions of saturated, monounsaturated, and polyunsaturated fatty acids (fSFA, fMUFA, and fPUFA) were estimated in VAT and SAT. SAT was further analyzed in deep and superficial compartments (dSAT and sSAT). In all depots, fPUFA was significantly higher and fSFA significantly lower in Iraqi men, independently of age and BMI. In both Iraqi- and Swedish-born men, higher fPUFA and lower fMUFA were found in sSAT vs. dSAT. Among Iraqi men only, higher fPUFA and lower fMUFA were found in SAT vs. VAT.Iraqi-born men presented a more favorable abdominal FAC compared to Swedish-born men. This MRI method also revealed different FACs in different abdominal depots. Our results may reflect a beneficial FAC in Middle Eastern immigrants.
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