Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 9, Issue 4, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofac092
Keywords
Acinetobacter baumannii; combination therapy; antimicrobial resistance; pneumonia; sulbactam-durlobactam
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This study reports a case of a critically ill patient with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach was used to guide the rational combination antimicrobial therapy through whole-genome sequencing, susceptibility testing, and synergy analysis.
We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.
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