Journal
PHARMACEUTICS
Volume 14, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics14040747
Keywords
curcumin; gentamicin sulfate; drug delivery; in situ gels; simultaneously loaded niosomes; stimuli-responsiveness; poloxamer; vesicular systems
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Funding
- Bulgarian National Science fund [KPi-06-H43/3-2020]
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The current study describes the development of a hybrid drug delivery platform using thermosensitive niosomal in situ gels for intravesical drug delivery. The optimized formulation achieved high entrapment efficiency and suitable physicochemical properties. The simultaneous loading of two drugs in the gel resulted in a synergistic effect, leading to sustained release. Therefore, this thermosensitive niosomal in situ gel can be considered as a feasible platform for intravesical drug delivery.
The current study describes the elaboration of a hybrid drug delivery platform for an intravesical application based on curcumin/gentamicin sulfate simultaneously loaded niosomes incorporated into thermosensitive in situ gels. Series of niosomes were elaborated via the thin film hydration method, evaluating the impact of non-ionic surfactants', cholesterol's, and curcumin's concentration. The formulation composed of equimolar ratio of Span 60, Tween 60, and 30 mol% cholesterol was selected as the optimal composition, due to the high entrapment efficiency values obtained for both drugs, and appropriate physicochemical parameters (morphology, size, PDI, and zeta potential), therefore, was further incorporated into Poloxamers (407/188) and Poloxamers and chitosan based in situ gels. The developed hybrid systems were characterized with sol to gel transition in the physiological range, suitable rheological and gelling characteristics. In addition, the formed gel structure at physiological temperatures determines the retarded dissolution of both drugs (vs. niosomal suspension) and sustained release profile. The conducted microbial studies of selected niosomal in situ gels revealed the occurrence of a synergetic effect of the two compounds when simultaneously loaded. The findings indicate that the elaborated thermosensitive niosomal in situ gels can be considered as a feasible platform for intravesical drug delivery.
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