Journal
PHARMACEUTICS
Volume 14, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics14030575
Keywords
colloidosomes; nanoparticles interaction; Pickering emulsions; nanodiamonds; layer-by-layer adsorption; thymoquinone; encapsulation
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Funding
- NRC Kurchatov Institute
- Ministry of Science and Higher Education of the Russian Federation
- Russian Foundation for Basic Research [18-53-34007]
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This study investigated the interaction between silica nanoparticles and nanodiamonds in an aqueous solution and developed submicron-sized colloidosomes using LbL technology. The modified capsules showed a significant delay in drug release and efficient internalization by cancer cells. The results demonstrate the high potential of nanomedicine in the development of drug delivery systems.
Capsules with shells based on nanoparticles of different nature co-assembled at the interface of liquid phases of emulsion are promising carriers of lipophilic drugs. To obtain such capsules, theoretically using the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory and experimentally using dynamic light-scattering (DLS) and transmission electron microscopy (TEM) methods, the interaction of like-charged silica nanoparticles and detonation nanodiamonds in an aqueous solution was studied and their ratios selected for the formation of submicron-sized colloidosomes. The resulting colloidosomes were modified with additional layers of nanoparticles and polyelectrolytes, applying LbL technology. As a model anti-cancer drug, thymoquinone was loaded into the developed capsules, demonstrating a significant delay of the release as a result of colloidosome surface modification. Fluorescence flow cytometry and confocal laser scanning microscopy showed efficient internalization of the capsules by MCF7 cancer cells. The obtained results demonstrated a high potential for nanomedicine application in the field of the drug-delivery system development.
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