Journal
PHARMACEUTICS
Volume 14, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics14050920
Keywords
zein; chitosan; self-assembly; nanoparticles; flash nanoprecipitation
Categories
Funding
- projects ZAPGO - FEDER, through COMPETE2020-Programa Operacional Competitividade e InternacionalizacAo [PTDC/NAN-MAT/28989/2017, POCI-01-0145-FEDER-031598]
- national funds (OE) through the Portuguese Foundation for Science and Technology (FCT/MCTES)
- European Union/ERDF [0633_BIOIMPACE_4_A]
- Portuguese Foundation for Science and Technology/MCTES [UIDB/00709/2020, UIDP/00709/2020]
- ESF
- European Regional Development Fund ERDF under the Interreg V A Spain-Portugal (POCTEP)
- [POCI-01-0145-FEDER-022122]
- Fundação para a Ciência e a Tecnologia [PTDC/NAN-MAT/28989/2017] Funding Source: FCT
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Zein and chitosan nanoparticles have been successfully prepared using an adapted anti-solvent nanoprecipitation method. Size-controlled zein-honey-chitosan nanoparticles were achieved through flash nanoprecipitation, which is a rapid and scalable self-assembly method. The size of the nanoparticles can be tuned by varying the formulation parameters.
Zein- and chitosan-based nanoparticles have been described as promising carrier systems for food, biomedical and pharmaceutical applications. However, the manufacture of size-controlled zein and chitosan particles is challenging. In this study, an adapted anti-solvent nanoprecipitation method was developed. The effects of the concentration of zein and chitosan and the pH of the collection solution on the properties of the zein-honey-chitosan nanoparticles were investigated. Flash nanoprecipitation was demonstrated as a rapid, scalable, single-step method to achieve the self-assembly of zein-honey-chitosan nanoparticles. The nanoparticles size was tuned by varying certain formulation parameters, including the total concentration and ratio of the polymers. The zein-honey-chitosan nanoparticles' hydrodynamic diameter was below 200 nm and the particles were stable for 30 days. Vitamin C was used as a hydrophilic model substance and efficiently encapsulated into these nanoparticles. This study opens a promising pathway for one-step producing zein-honey-chitosan nanoparticles by flash nanoprecipitation for hydrophilic compounds' encapsulation.
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