4.7 Article

Clinical Pharmacokinetic Assessment of Kratom (Mitragyna speciosa), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations

Rakshit S. Tanna et al.

Summary: Kratom's main alkaloid mitragynine has been shown to be a time-dependent inhibitor of hepatic and intestinal cytochrome P450 3A activity, potentially causing serious pharmacokinetic interactions with drugs. A static model predicted that mitragynine would increase systemic exposure to the probe drug midazolam by approximately 5.7-fold.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2021)

Article Plant Sciences

Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats

Shyam H. Kamble et al.

Summary: This study developed a method to simultaneously quantify the exposure of 11 kratom alkaloids in rat plasma. It was found that only a few alkaloids showed systemic exposure 8 hours postdose after oral administration.

JOURNAL OF NATURAL PRODUCTS (2021)

Article Public, Environmental & Occupational Health

Drug and Opioid-Involved Overdose Deaths - United States, 2017-2018

Nana Wilson et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

Editorial Material Biochemistry & Molecular Biology

Generational trends in US opioid-overdose deaths

Wayne Hall et al.

NATURE MEDICINE (2020)

Article Pharmacology & Pharmacy

A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies

Caroline Birer-Williams et al.

DRUG METABOLISM AND DISPOSITION (2020)

Article Plant Sciences

Pharmacokinetics and Safety of Mitragynine in Beagle Dogs

Elizabeth A. Maxwell et al.

PLANTA MEDICA (2020)

Article Chemistry, Medicinal

Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

Shyam H. Kamble et al.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2020)

Article Public, Environmental & Occupational Health

Unintentional Drug Overdose Deaths with Kratom Detected-27 States, July 2016-December 2017

Emily O'Malley Olsen et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2019)

Article Chemistry, Multidisciplinary

7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

Andrew C. Kruegel et al.

ACS CENTRAL SCIENCE (2019)

Review Biochemistry & Molecular Biology

Selection and characterization of botanical natural products for research studies: a NaPDI center recommended approach

Joshua J. Kellogg et al.

NATURAL PRODUCT REPORTS (2019)

Review Behavioral Sciences

From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction

Zurina Hassan et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2013)

Article Substance Abuse

The use of Mitragynine speciosa (Krathom), an addictive plant, in Thailand

Sawitri Assanangkornchai et al.

SUBSTANCE USE & MISUSE (2007)

Review Chemistry, Medicinal

Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa

H Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN (2004)

Article Chemistry, Multidisciplinary

Harmonized guidelines for single-laboratory validation of methods of analysis - (IUPAC technical report)

M Thompson et al.

PURE AND APPLIED CHEMISTRY (2002)