Journal
NPJ BIOFILMS AND MICROBIOMES
Volume 8, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41522-022-00295-y
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Funding
- Centre for Translational Microbiome Research (CTMR)
- Karolinska Institutet
- Ferring Pharmaceuticals
- Swedish Research Council (VR) [2021-01683]
- Swedish Foundation for Strategic Research [ICA16-0050]
- Jeanssons Foundation [JS2017-0141, JS2018-0034]
- Svenska Lakaresallskapet [SLS-784981, SLS-960584]
- Karolinska Institute Foundation
- Swedish Foundation for Strategic Research (SSF) [ICA16-0050] Funding Source: Swedish Foundation for Strategic Research (SSF)
- Swedish Research Council [2021-01683] Funding Source: Swedish Research Council
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Bacterial vaginosis is a common vaginal infection that is usually treated with antibiotics, despite high recurrence rate. Clinical trials with probiotics have shown mixed results. Therefore, large-scale trials using the correct strains of bacteria directly administered into the vagina are needed.
Bacterial vaginosis (BV) is a condition in which the vaginal microbiome presents an overgrowth of obligate and facultative anaerobes, which disturbs the vaginal microbiome balance. BV is a common and recurring vaginal infection among women of reproductive age and is associated with adverse health outcomes and a decreased quality of life. The current recommended first-line treatment for BV is antibiotics, despite the high recurrence rate. Live biopharmaceutical products/probiotics and vaginal microbiome transplantation (VMT) have also been tested in clinical trials for BV. In this review, we discuss the advantages and challenges of current BV treatments and interventions. Furthermore, we provide our understanding of why current clinical trials with probiotics have had mixed results, which is mainly due to not administering the correct bacteria to the correct body site. Here, we propose a great opportunity for large clinical trials with probiotic strains isolated from the vaginal tract (e.g., Lactobacillus crispatus) and administered directly into the vagina after pretreatment.
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