Journal
JOURNAL OF ADVANCED RESEARCH
Volume 44, Issue -, Pages 227-232Publisher
ELSEVIER
DOI: 10.1016/j.jare.2022.04.011
Keywords
Nasal spray; Nasal spray deposition; Nasal cast; Nose-to-brain delivery; Deposition pattern; Viscosity
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This study optimized a method for evaluating the nasal deposition and coverage of innovative nasal spray nozzles. It was found that aerosol formulations with droplets of 15-25 μm in size could be uniformly deposited in the nasal cavity, with less than 10% passing beyond the nasopharyngeal region.
Introduction: The characterisation of nasal formulations is a critical point. However, there are still no rec-ommendations or guidelines in terms of standard approaches for evaluating the formulation's nasal deposition and/or coverage profile. This study optimises a method for quantifying silicone nasal cast deposition and coverage of liquid formulations using different nasal devices.Objectives: The present work investigates the nasal deposition and coverage patterns of innovative nasal spray nozzles producing slow velocity soft mists, using a nasal cavity replica and a fluorescent dye. Methods: The study of the deposition pattern of a fluorescent liquid formulation in a transparent nasal cast was carried out in both the presence and absence of a simulated inhalation flow. The extent of the deposition pattern was investigated using ImageJ and fluorescence in the nasal cast, quantified by flu-orometric analysis. The particle size distribution and initial droplet velocity were determined using a laser diffractometer and a high-speed camera with a frame rate of 1000 fps.Results: A uniform intranasal coverage was obtained with droplets of a volume median particle size (Dv50) between 15 and 25 lm in airflow between 10 and 30 L/min. In these conditions, aerosol formu-lations can be uniformly deposited in the vestibule and turbinate cavity nasal regions, with less than 10 % passing beyond the nasopharyngeal region.Conclusion: The method applied allowed for the determination of the coverage of the nasal cast in differ-ent regions using images analysis and fluorometric analysis. Droplet velocity is a critical parameter in the deposition in the nasal cavity. With standard swirl nozzles, many droplets are found on the surface of the nasal vestibule. Soft mist nozzles produce smaller droplets at a much lower initial velocity (<1 m/s), resulting in a more uniform coverage.(c) 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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